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Dipeptide frequencies in proteins and the CpG deficiency in vertebrate DNA

Journal of Molecular Evolution volume 1, pages 315–325 (1972)Cite this article

Summary

Analysis of vertebrate protein sequences totalling 4040 residues shows that amino acids with a high proportion of codons ending in C occur with significantly reduced frequency before amino acids whose codons start with G. This effect is not shown by “control” bacterial protein sequences. The consequent implication of shortage of XXC. GXX codon pairs in vertebrate messenger RNA is discussed in relation to the extreme rarity of the base doublet CpG in vertebrate DNA.

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Affiliations

  1. Department of Chemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada

    E. Bullock

  2. M.R.C. Virology Unit, Church Street, G11 5JR, Glasgow, U.K.

    R. A. Elton

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  1. E. Bullock
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  2. R. A. Elton
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Bullock, E., Elton, R.A. Dipeptide frequencies in proteins and the CpG deficiency in vertebrate DNA. J Mol Evol 1, 315–325 (1972). https://doi.org/10.1007/BF01653960

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  • DOI: https://doi.org/10.1007/BF01653960

Key words

  • Vertebrate Protein Sequences
  • Doublet Frequencies
  • CpG Deficiency