Abstract
Transcatheter arterial embolization (TAE) combined with transcatheter arterial infusion (TAI) was done in 58 patients with unresectable hepatic malignancies. The actuarial 1-year survival rate of the patients was 56.2%. Elective hepatic resection was performed on 10 patients following these procedures. These patients are all doing well. Complete tumor necrosis was demonstrated in 5 of these 10 patients by pathohistological studies on resected specimens from 1 to 11 months after surgery. These tumors were solitary, small (less than 4 cm in diameter), encapsulated, and located deeply inside the liver, being supplied by a single artery. In the other 5 patients, tumor cells in the main tumor and/or in daughter nodules were viable. We conclude that TAE combined with TAI was justified for treatment of hepatic malignancies in selected cases.
Résumé
L'embolisation artérielle associée avec la perfusion artérielle d'un agent chimique a été employée chez 58 malades qui présentaient des tumeurs hépatiques impossible à réséquer. La survie actuarielle à un an a ét de 56%.
Chez 10 des malades ainsi traités il fut possible de pratiquer ultérieurement une résection hépatique. Ils sont tous en bonne santé.
Chez 5 de ces 10 opérés on a pu constater de 1 à 11 mois après l'intervention que la tumeur était totalement nécrosée. Il s'agissait de tumeurs solitaires, de diamètre inférieur à 4 cm, encapsulées, situées profondément dans le foie et vascularisée par une seule artère. Chez les 5 autres malades des cellules néoplasiques persistaient au sein de la tumeur et la lésion principale s'accompagnaient de nodules néoplasiques satellites.
L'embolisation artérielle associée avec la perfusion artérielle d'un agent chimique se trouve ainsi justifiée. Elle s'applique à certains cas de tumeurs malignes du foie bien sélectionnées.
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Presented before the meeting of the International Society of Surgery, Montreux, Switzerland, September, 1981.
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Okamura, J., Horikawa, S., Fujiyama, T. et al. An appraisal of transcatheter arterial embolization combined with transcatheter arterial infusion of chemotherapeutic agent for hepatic malignancies. World J. Surg. 6, 352–357 (1982). https://doi.org/10.1007/BF01653556
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DOI: https://doi.org/10.1007/BF01653556