Abstract
Antibiotic prophylaxis should be used a) where the risk of infection is high; b) where bacterial contamination is high; where contamination is infrequent but the consequences of infection are high; and c) where contamination is infrequent but the host is compromised. Careful attention should be given the selection of an appropriate agent for the given circumstance. Timing and route of administration are also important factors.
Résumé
L'antibiothérapie à titre prophylactique est indispensable alors que le risque de contamination est faible mais que les conséquences de l'infection sont importantes. Une attention particulière doit être accordée aux choix de l'antibiotique en fonction des circonstances données. Le moment et la voie d'administration doivent êgalement être pris en considération.
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References
Burke, J.F.: The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery50:161, 1969
Stone, H.H., Hooper, C.A., Kolb, L.B., Geheber, C.E., Dawkins, E.J.: Antibiotic prophylaxis in gastric, biliary and colonic surgery. Ann. Surg. 184:443, 1976
Downing, R., McLeish, A.R., Burdon, D.W., Alexander-Williams, J., Keighley, M.R.B.: Duration of systemic prophylactic antibiotic cover against anaerobic sepsis in intestinal surgery. Dis. Colon Rectum20:401, 1977
Strachan, C.J.L., Black, J., Powis, S.J.A., Waterworth, T.A., Wise, R., Wilkinson, A.R., Burdon, D.W., Stevern, M., Mitra, B., Norcott, H.: Prophylactic use of cephazolin against wound sepsis after cholecystectomy. Br. Med. J.1:1254, 1977
Evans, C., Pollock, A.V., Rosenberg, I.L.: The reduction of surgical wound infection by prophylactic parenteral cephaloridine. Br. J. Surg.61:133, 1974
Nichols, R.L., Condon, R.E., Gorbach, S.L., Nyhus, L.: Efficacy of preoperative antimicrobial preparation of the bowel. Ann. Surg.172:257, 1972
Arabi, Y., Dimock, F., Burdon, D.W., AlexanderWilliams, J., Keighley, M.R.B.: Influence of bowel preparation and antimicrobials on colonic microflora. Br. J. Surg.65:555, 1978
Keighley, M.R.B., Arabi, Y., Alexander-Williams, J., Youngs, D., Burdon, D.W.: Comparison between systemic and oral antimicrobial prophylaxis in colorectal surgery. Lancet1:894, 1979
Finch, D.R.A., Taylor, L., Morris, P.J.: Wound sepsis following gastro-intestinal surgery: A comparison of topical and two-dose systemic cephradine. Br. J. Surg.66:580, 1979
Gatehouse, D., Dimock, F., Burdon, D.W., Alexander-Williams, J., Keighley, M.R.B.: Prediction of wound sepsis following gastric operations. Br. J. Surg.65:551, 1978
Keighley, M.R.B.: Micro organisms in the bile. Ann. R. Coll. Surg. Engl.59:328, 1977
Bivens, M., Neufeld, J., McCarth, W.D.: The prophylactic use of Keflex and Keflin in vaginal hyster-ectomy. Am. J. Obstet. Gynecol.122:169, 1975
Weightman, J.A.K.: A prospective survey of the incidence of post-operative pulmonary complications. Br. J. Surg.55:86, 1968
Cruse, P.J.E., Foord, R.: A five-year prospective study of 23,649 surgical wounds. Arch. Surg.107:206, 1973
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Keighley, M.R.B. A rational approach to antibiotic prophylaxis in surgery. World J. Surg. 6, 327–329 (1982). https://doi.org/10.1007/BF01653549
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DOI: https://doi.org/10.1007/BF01653549