Abstract
Infection is a problem in biliary surgery and precautions should be taken to reduce this. A policy for the prophylactic use of antibiotics is essential. Patients who are at risk should be identified by assessment of clinical parameters and/or by duodenal intubation and immediate plating of the bile specimen. The antibiotic should be carefully chosen after consultation with the bacteriology department. Prospective collection of data should begin with specimens of gallbladder wall, bile, and a stone sent for both aerobic and anaerobic culture. The selected antibiotic should be started preoperatively.
Résumé
L'infection est une complication relativement fréquente de la chirurgie biliaire. Toutes les précautions doivent être prises pour l'éviter. L'emploi des antibiotiques à titre prophylactique est essentiel. Les patients qui présentent un risque élevé doivent être identifiés à l'aide des données cliniques et/ou par l'examen bactériologique de la bile obtenue par aspiration duodénale. L'antibiotique doit être alors soigneusement choisi.
Au décours de l'intervention la recherche de germes aérobies et anaérobies au niveau de la paroi vésiculaire, de la bile et des calculs doit être entreprise pour établir l'antibiogramme et sélectionner le meilleur antibiotique.
Similar content being viewed by others
References
McSherry, C.K., Glenn, F.: The incidence and cause of death following surgery for non-malignant biliary tract disease. Ann. Surg.191:271, 1980
Scottish Hospitals Inpatient statistics. Edinburgh. HMSO 1977, 1978
Edinburgh Surgical audit report. (Local publication) 1977–80
Department of Surgery reports. Edinburgh (Local publication) 1964–1976
Keighley, M.R.B., Lister, D.M., Jacobs, S.I., Giles, G.R.: Hazards of surgical infection due to microorganisms in the bile. Surgery75:578, 1974
Robson, M.C., Bogart, J.N., Heggers, J.P.: An endogenous source for wound infection based on quantitative bacteriology of the biliary tract. Surgery68:471, 1970
Keighley, M.R.B.: Microorganisms in the bile, a preventable cause of sepsis after biliary surgery. Ann. R. Coll. Surg. Engl.59:328, 1977
Strachan, C.J.L., Black, J., Powis, S.J.A.: Use of Cephazol against wound sepsis after cholecystectomy. Br. Med. J.1:1254, 1977
Haw, S., Gunn, A.A.: The significance of infection in biliary surgery. J. R. Coll. Surg. Edin.18:209, 1973
Gunn, A.A.: Abdominal drainage. Br. J. Surg.56:274, 1969
Carlson, H.C.: Percutaneous cholangiography. Med. Clin. North Am.54:875, 1970
Huang, T., Bass, J.A., Williamson, R.D.: The significance of biliary pressure in cholangitis. Arch. Surg.98:629, 1969
McLean, L.D., Goldstein, M., MacDonald, J.E: Results of biliary surgery in 1000 consecutive patients. Can. J. Surg.18:459, 1975
Edlund, Y.A., Mollstedt, B.O., Ouchterlony, O.: Bacteriological investigation of the biliary system and liver. Acta Chir. Scand.116:461, 1959
Dye, M., Macdonald, A., Smith, G.: The bacterial flora of the biliary tract and liver in man. Br. J. Surg.65:285, 1978
Roullier, C.: Les canilicules biliaires; étude au microscope électronique. Acta Anat. (Basel)26:94, 1956
Keighley, M.R.B., Burdon, D.W.: Identification of the bacteria in the bile by duodenal aspiration. World J. Surg.2:255, 1978
McLeish, A.R., Keighley, M.R.B., Bishop, H.M.L.: Selecting patients requiring antibiotics in biliary surgery by immediate staining. Surgery81:473, 1977
Acocella, R., Mattiussi, R.B., Nicholas, F.B.,et al.: Biliary excretion of antibiotics in man. Gut9:536, 1968
Truim, J.R., Gillette, L., Berger, W.V.: The role of antibiotics in infection of the biliary tract. Ann. Surg.144:1008, 1956
Keighley, M.R.B., Drysdale, R.B., Quoraishi, A.H., Burdon, D.W., Alexander-Williams, J.: Antibiotics in biliary disease—The relative importance of antibiotic concentration in the bile and serum. Gut17:495, 1976
Keighley, M.R.B., Graham, C.: Infective cholecystitis. J. R. Coll. Surg. Edinb.18:213, 1973
Gunn, A.A.: Antibiotics in biliary surgery. Br. J. Surg.63:627, 1976
Evans, C., Pollock, I.V.: Reduction of surgical wound infection by prophylactic parenteral cephaloridine. Br. J. Surg.60:434, 1973
Maddocks, A.C.L., Hilson, G.R.F., Taylor, R.: The bacteriology of the obstructed biliary tract. Ann. R. Coll. Surg. Engl.52:316, 1973
Stone, H.M., Hooper, C.A., Kolb, L.D., Geheber, C.E., Dawkins, E.J.: Antibiotic prophylaxis in gastric biliary and duodenal surgery. Ann. Surg.184:443, 1976
Strachan, C.J.L., Black, J., Powis, S.J.A., Waterworth, T.A., Wise, R., Wilkinson, A.R., Burdon, D.A., Stevern, M., Mitra, B., Norcott, H.: The prophylactic use of cephazolin against wound sepsis after cholecystectomy. Br. Med. J.1:1254, 1977
Raine, P.A.M., Gunn, A.A.: Acute cholecystitis. Br. J. Surg.62:697, 1975
Keighley, M.R.B., Baddeley, R.M., Burdon, D.W., Edwards, J.A.C., Quoraishi, A.H., Oates, G.D., Watts, G.T., Alexander-Williams, J.: A controlled trial of parenteral prophylactic gentamicin therapy in biliary surgery. Br. J. Surg. 62:275, 1975
Stewart, D.: Generalised peritonitis. J. R. Coll. Surg. Edinb.25:80, 1980
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gunn, A.A. Antimicrobial prophylaxis in biliary surgery. World J. Surg. 6, 301–305 (1982). https://doi.org/10.1007/BF01653545
Issue Date:
DOI: https://doi.org/10.1007/BF01653545