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Virus-associated haemophagocytic syndrome with Epstein-Barr virus infection

Virchows Archiv A volume 419, pages 519–522 (1991)Cite this article

Summary

The clinical and histological findings of a 10-year-old girl with virus-associated haemophagocytic syndrome are presented. The serum levels of Epstein-Barr viral antigens were elevated. Epstein-Barr virus (EBV) genome was detected by polymerase chain reaction in bone marrow and lymph node specimens. Histologically, haemophagocytic histiocytes were present in bone marrow, and areas of non-suppurative necrosis were present in lymph nodes, where silver grain deposition of the EBV genome was demonstrated by in situ hybridization.

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Affiliations

  1. Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jyonan-ku, 814-01, Fukuoka, Japan

    Kohichi Ohshima, Masahiro Kikuchi, Fuyuki Eguchi & Shinichi Kobari

  2. Department of Pediatrics, Kyushu Cancer Center Hospital, Fukuoka, Japan

    Hideko Tasaka

Authors
  1. Kohichi Ohshima
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  2. Masahiro Kikuchi
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  3. Fuyuki Eguchi
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  4. Shinichi Kobari
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  5. Hideko Tasaka
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Ohshima, K., Kikuchi, M., Eguchi, F. et al. Virus-associated haemophagocytic syndrome with Epstein-Barr virus infection. Vichows Archiv A Pathol Anat 419, 519–522 (1991). https://doi.org/10.1007/BF01650682

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  • DOI: https://doi.org/10.1007/BF01650682

Key words

  • Virus-associated haemophagocytic syndrome
  • Epstein-Barr virus
  • In situ
  • Polymerase chain reaction