Summary
A single dose therapy of 500 mg ciprofloxacin was sufficient to cure 15 of 18 chancroid patients within six days and the remaining three within 7, 11 and 20 days respectively. The drug was well tolerated, and no serious side effects were observed. The MICs of ciprofloxacin for the isolatedHaemophilus ducreyi strains ranged from 0.0015 to 0.02 mg/l (mean 0.01 mg/l). It may therefore be concluded from our study that the oral administration of ciprofloxacin to chancroid patients with or without buboes is highly effective and free from side effects.
Zusammenfassung
Mit einer Einzeldosis Ciprofloxacin in Form der 500-mg-Tablette wurden 15 von 18 Patienten mit Chankroid innerhalb sechs Tagen geheilt; bei den übrigen drei Patienten dauerte die Heilung sieben, 11 und 20 Tage. Das Medikament wurde gut vertragen. Ernsthafte Nebenwirkungen traten nicht auf. Die MHK-Werte derHaemophilus dycreyi-Isolate lagen zwischen 0,0015 und 0,02 mg Ciprofloxacin/l (Mittelwert 0,01 mg/l). Aus unseren Erfahrungen läßt sich ableiten, daß die orale Therapie des Chancroid bei Patienten mit oder ohne Bubonen hochwirksam und nebenwirkungsfrei ist.
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Literature
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Traisupa, A., Wongba, C. & Tesavibul, P. Efficacy and safety of a single dose therapy of a 500 mg ciprofloxacin tablet in chancroid patients. Infection 16 (Suppl 1), S44–S45 (1988). https://doi.org/10.1007/BF01650505
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DOI: https://doi.org/10.1007/BF01650505