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Ciprofloxacin concentrations in tonsils following single or multiple administrations

Ciprofloxacin-Tonsillenkonzentration nach einmaliger oder mehrmaliger intravenöser Applikation

  • Pharmacokinetic Studies
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Summary

Penetration of ciprofloxacin into human tonsils was studied in 20 adult humans undergoing tonsilectomy. Ten patients received a single intravenous infusion of 200 mg ciprofloxacin within 15 min (group A) and 14 patients were treated orally for three days with 500 mg ciprofloxacin b.i.d. prior to a preoperative infusion of 200 mg (group B). Ciprofloxacin concentrations in serum and tonsils were determined microbiologically. Mean ciprofloxacin serum concentrations did not differ significantly between both groups. Similarly, mean distribution ratios between tonsils and serum were not dissimilar, being on average 150% irrespective of whether the drug was administered once or repeatedly. Thus, a significant accumulation of ciprofloxacin was not observed either in the intravascular or in the extravascular space.

Zusammenfassung

Die Penetration von Ciprofloxacin in Tonsillen wurde an 20 erwachsenen Patienten, die sich einer Tonsillektomie unterziehen mußten, untersucht. Zehn Patienten erhielten eine einmalige Infusion von 200 mg Ciprofloxacin (Gruppe A) und weitere 14 Patienten erhielten eine dreitägige orale Therapie mit 500 mg Ciprofloxacin zweimal täglich vor der anschließenden perioperativen Infusion von 200 mg (Gruppe B). Die Ciprofloxacin-Konzentrationen in Serum und Tonsillen wurden mikrobiologisch bestimmt. Die mittleren Ciprofloxacin-Serumkonzentrationen waren zwischen beiden Gruppen nicht signifikant verschieden. Gleichermaßen betrug das mittlere Verteilungsverhältnis zwischen Tonsillen und Serum 150% unabhängig, ob die Substanz einmal oder mehrfach verabreicht wurde. Somit wurde weder im intra- noch im extravaskulären Raum eine signifikante Kumulation von Ciprofloxacin beobachtet.

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Authors and Affiliations

  1. ENT Clinic of the University of Innsbruck, Anichstraße 35, A-6020, Innsbruck

    N. Falser

  2. Bayer AG, Pharma Research Center, P. O. Box 10 17 09, D-5600, Wuppertal

    A. Dalhoff &  H. Weuta

Authors
  1. N. Falser
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  2. A. Dalhoff
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  3. H. Weuta
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Falser, N., Dalhoff, A. & Weuta, H. Ciprofloxacin concentrations in tonsils following single or multiple administrations. Infection 16 (Suppl 1), S14–S18 (1988). https://doi.org/10.1007/BF01650501

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