Skip to main content
SpringerLink
Log in

Antimicrobial effects of niridazole on gardnerella vaginalis

Antimikrobielle Wirkung von Niridazol gegen Gardnerella vaginalis

  • Brief Communication
  • Published:
Infection Aims and scope Submit manuscript

Summary

Niridazole, a nitrothiazole derivative, demonstrated powerful antimicrobial activity against 510 clinical isolates ofGardnerella vaginalis tested. MIC's ranged from 0.002 to 1.0 mg/l with MIC50 and MIC90 values of 0.02 and 0.067 mg/l, respectively.

Zusammenfassung

Niridazol, ein Nitrothiazol-Derivat, wies bei der Testung von 510 klinischen Isolaten vonGardnerella vaginalis hohe antimikrobielle Wirksamkeit gegen diesen Erreger auf. Die MHK-Werte waren im Bereich von 0,002 bis 1,0 mg/l; die MHK50 lag bei 0,02 mg/l, die MHK90 bei 0,067 mg/l.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literature

  1. Hof, H., Sticht-Groh, V., Muller, K.-M. Comparativein vitro activities of niridazole and metronidazole against anaerobic and microaerophilic bacteria. Antimicrob. Agents Chemother. 22 (1982) 332–333.

    Google Scholar 

  2. Smith, R. F., Dunkelberg, W. E. Inhibition ofCorynebacterium vaginale by metronidazole. Sex. Trans. Dis. 4 (1977) 20–21.

    Google Scholar 

  3. Freydiere, A. M., Gille, Y., Tigaud, S., Vincent, P. In vitro susceptibilities of 40Campylobacter fetus subsp.jejuni strains to niridazole and metronidazole. Antimicrob. Agents Chemother. 25 (1984) 145–146.

    Google Scholar 

  4. Hof, H., Sticht-Groh, V. Antibacterial effects of niridazole: Its effect on microaerophilic campylobacter. Infection 12 (1984) 36–39.

    Google Scholar 

  5. Hof, H., Rieffert, M., Sticht-Groh, V., Zak, O., Schweizer, E. Antibacterial activities of nitrothiazole againstCampylobacter jejuni andCampylobacter coli. Antimicrob. Agents Chemother. 27 (1984) 498–500.

    Google Scholar 

  6. Jolly, J. L. S. Minimal criteria for the identification ofGardnerella vaginalis isolated from the vagina. J. Clin. Pathol. 36 (1983) 476–478.

    Google Scholar 

  7. Reed, L. J., Muench, H. A simple method for estimating fifty per cent end points. Amer. J. Hyg. 27 (1938) 493–497.

    Google Scholar 

  8. Taylor, E., Blackwell, A. L., Barlow, D., Phillips, I. Gardnerella vaginalis, anaerobes, and vaginal discharge. Lancet I (1982) 1376–1379.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Bacteriology, The Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, Ontario, Canada

    R. M. Bannatyne M.B., Ch.B. & J. Jackowski

Authors
  1. R. M. Bannatyne M.B., Ch.B.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Jackowski
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bannatyne, R.M., Jackowski, J. Antimicrobial effects of niridazole on gardnerella vaginalis. Infection 15, 128 (1987). https://doi.org/10.1007/BF01650215

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01650215

Keywords

Search

Navigation