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Prevention of herpes simplex virus infections in susceptible patients

Prävention von Herpes simplex Virus-Infektionen bei gefähredeten Patienten

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Summary

Immunocompromised patients are at high risk of developing herpes simplex virus infections caused by reactivation of the virus. Intravenous and oral formulations of acyclovir have been shown to prevent most of these infections during the major at-risk periods when given prophylactically. Immunocompetent patients may also experience reactivation of herpes simplex virus leading most often to recurrent genital or labial infections. For those patients who experience frequent attacks, oral acyclovir can prevent most recurrences and is well tolerated when given as continuous suppressive therapy.

Zusammenfassung

Bei Patienten mit beeinträchtigter Immunität besteht ein hohes Risiko für Herpes simplex Virus-Infektionen durch Reaktivierung des Virus. Es hat sich gezeigt, daß durch prophylaktische Gabe der intravenösen oder oralen Zubereitungsform von Aciclovir die meisten dieser Infektionen während der Phasen des größten Risikos verhütet werden können. Bei immunkompetenten Patienten treten ebenfalls durch Reaktivierung des Herpes simplex Virus Infektionen auf, die sich am häufigsten als rezidivierender Herpes genitalis oder labialis manifestieren. Bei Patienten, die sehr häufig Herpes-Schübe durchmachen, kann durch eine kontinuierliche orale Suppressionstherapie mit Aciclovir das Auftreten von Rezidiven weitgehend verhindert werden.

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  1. Clinical Antiviral Therapy Section, Wellcome Research Laboratories, Beckenham, Kent, England

    A. P. Fiddian M.B., B.S.

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Fiddian, A.P. Prevention of herpes simplex virus infections in susceptible patients. Infection 15 (Suppl 1), S21–S25 (1987). https://doi.org/10.1007/BF01650107

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