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Thromboxane production and platelet aggregation in type 2 diabetes mellitus without vascular complications

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Summary

Diabetic individuals frequently have platelet hyperaggregability and increased thromboxane (TXB2) production. To evaluate whether improvement of metabolic control or changes in fatty acid composition of serum lipids might alter thromboxane (TXB2) formation and platelet function, we followed up 25 newly diagnosed type 2 diabetics without angiopathy for about 6 months. Improvement of metabolic control (HbA1, fell from 12.0±0.3 to 9.0±0.3%;p<0.01) was associated with significant decrease in total cholesterol, triglycerides, and ratios of total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol. Palmitic acid of phospholipids decreased significantly, whereas eicosapentaenoic acid increased. Regardless of this, the ADP-induced platelet aggregability and sensitivity were not altered. There was no effect whatever on the TXB2 synthesis capacity of clotting whole blood (204.9±25.0 vs 222.8±32.0 ng/ml) over 6 months of treatment. Platelet aggregability and TXB2 formation were not correlated to the degree of metabolic control, nor were there any correlations to serum lipids and their fatty acid composition. Thus, we are tempted to speculate that glucose metabolism in diabetes itself does not affect platelet aggregation or TXB2 formation in type 2 diabetes mellitus.

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Abbreviations

TXB2 :

Thromboxane B2

HbA1 :

Glycosylated hemoglobin A1

HDL:

High density lipoproteins

LDL:

Low density lipoproteins

ADP:

Adenosine diphosphate

P/S Ratio:

Polyunsaturated fatty acids/saturated fatty acids ratio

ECG:

Electrocorticogram

TAC 50:

Threshold aggregating concentration eliciting 50% of maximal response

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Authors and Affiliations

  1. Institut für Diabetes und Stoffwechselkrankheiten, Berlin

    K. P. Ratzmann, E. Schimke & R. Hildebrandt

  2. Institut für Pharmakologie und Toxikologie, Martin Luther Universität Halle-Wittenberg, Deutschland

    A. Beitz & C. Taube

Authors
  1. K. P. Ratzmann
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  2. E. Schimke
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  3. A. Beitz
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  4. R. Hildebrandt
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  5. C. Taube
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Ratzmann, K.P., Schimke, E., Beitz, A. et al. Thromboxane production and platelet aggregation in type 2 diabetes mellitus without vascular complications. Klin Wochenschr 69, 652–656 (1991). https://doi.org/10.1007/BF01649426

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  • DOI: https://doi.org/10.1007/BF01649426

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