Summary
Following the elementary laws of hemodynamics and the functional characteristics of the renal myogenic and macula densa-mediated (TGF) vascular resistance control mechanisms, TGF-mediated changes of renal vascular resistance are amplified by cooperative changes of the myogenic mechanism. Myogenically induced changes, on the other hand, would be antagonized by TGF. Resetting of renal vascular flow resistance by alterations to the TGF mechanisms might thus be more effective than alterations to the myogenic mechanism. Dopamine and adenosine, two autacoids occurring normally in the tubular fluid, may play a key role in operating such a resetting mechanism. Dopamine and adenosine were found in proximal tubular fluid at concentrations of 10−8 and 0.5 10−6 M respectively. Dopamine inhibits the tubuloglomerular feedback mechanism, this inhibition is antagonized concentration-dependently by adenosine. These effects most likely occur via D1 and A1 receptors and hence by regulation of the adenyl cyclase activity in the macula densa cells. The balance between adenosine and dopamine in tubular fluid appears to be under the control of extrarenal parameters. In normal rats, high dietary salt intake, by influencing the secretion of an unknown adrenal hormone, and inhibition of Na-K-ATPase might be of importance. In spontaneously hypertensive rats unknown genetic parameters may also play a role.
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Abbreviations
- TGF:
-
tubuloglomerular feedbackmechanism
- SFP:
-
stopped flow pressure
- SNGFR:
-
Single nephron glomerular filtration rate
- ATF:
-
Artifical proximal tubular fluid
- TF:
-
Tubular fluid
- ADX:
-
Acutely Adrenalectomized
- SHR:
-
Spontaneous hypertensive Rat
- KW:
-
Kidney weight
- ANO-VA:
-
Analysis of variance
- “EC50”:
-
Half-maximal activity
- HPLC:
-
High performance liquid chromatography
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Preprint of a lecture to be read at the 22nd Congress of the “Gesellschaft für Nephrologie”, Heidelberg, September 15–18, 1991 (Editor: Prof. Dr. E. Ritz, Heidelberg)
Supported by Deutsche Forschungsgemeinschaft Ha 775/9-2, 11-1
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Häberle, D.A., Königbauer, B., Kawabata, M. et al. Renal blood flow control by tubuloglomerular feedback (TGF) in normal and spontaneously hypertensive rats — a role for dopamine and adenosine. Klin Wochenschr 69, 587–596 (1991). https://doi.org/10.1007/BF01649321
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DOI: https://doi.org/10.1007/BF01649321