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New horizons in renal vasculitis

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Summary

After a long period during which few new data on the vasculitides emerged, the past decade has seen a real explosion of data on the subject. This began with basic clinical descriptions and the deliniation of long term outcome as survival improved to a major extent under the influence of improved treatment regimes. In parallel, better understanding of the immunopathology has emerged. Of particular interest have been descriptions of autoantibody systems in vasculitis which seem to be specific to vasculitis and therefore diagnostically useful: the antineutrophil cytoplasmic antibodies (ANCA). Whether or not these are pathogenetically significant as well as useful remains a matter for debate. In parallel, anti endothelial cell antibodies have been described, but their role (if any), in pathogenesis remains equally obscure. There are some suggestions that vasculitis is becoming more common, but increased awareness and the availability of ANCA have undoubtedly increased awareness of the subject.

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Abbreviations

AECA:

anti endothelial cell antibodies

ACR:

American College of Rheumatology

ANCA:

anti neutophil cytoplasmic antibodies

DNA:

deoxyribonucleic acid

ESR:

erythrocyte sedimentation rate

HLA:

human leukocyte antigen

NSAID:

non steroidal anti-inflammatory drug

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  1. United Medical and Dental Schools of Guy's and St Thomas's Hospitals, Guy's Campus, London, UK

    J. S. Cameron

  2. Clinical Science Laboratories, Guy's Hospital, 17th Floor Guy's Tower, SE1 9RT, London, UK

    J. S. Cameron

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Preprint of a lecture to be read at the 22nd Congress of the “Gesellschaft für Nephrologie”, Heidelberg, September 15–18, 1991 (Editor: Prof. Dr. E. Ritz, Heidelberg)

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Cameron, J.S. New horizons in renal vasculitis. Klin Wochenschr 69, 536–551 (1991). https://doi.org/10.1007/BF01649316

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