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HIV antigen, HIV antibody and serum interferon in a patient with encephalopathy

HIV-Antigen, HIV-Antikörper und Serum Interferon bei einem Patienten mit akuter Enzephalopathie

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Summary

Acute encephalopathy was associated with the presence of human immunodeficiency virus type I (HIV I) antigen and seroconversion to anti-HIV I in a 27-year-old homosexual man. Examination of consecutive sera from the patient revealed circulating interferon (IFN) alpha which became detectable with the appearance of HIV I antigen but before development of anti-HIV I. Serum IFN was present for only a limited time and was not demonstrable after neurological symptoms resolved. It may be speculated that circulating antiviral activity contributed to the clinical manifestations of acute HIV I infection.

Zusammenfassung

Der Nachweis von Human Immunodeficiency Virus Typ I (HIV I) Antigen und die Entwicklung von Anti-HIV I war bei einem 27 Jahre alten Homosexuellen mit akuter Enzephalopathie verbunden. Die Untersuchung von sequentiell entnommenen Patientenseren ergab, daß zirkulierendes Interferon (IFN) alpha gleichzeitig mit dem Auftreten von HIV-I-Antigen, aber vor der Entwicklung von Anti-HIV I nachgewiesen werden konnte. Serum IFN alpha war nur für einen begrenzten Zeitraum und nicht nach der Rückbildung der neurologischen Symptome nachweisbar. Die mögliche Beteiligung zirkulierender antiviraler Aktivität an den klinischen Manifestationen der akuten Infektion mit HIV I wird diskutiert.

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Authors and Affiliations

  1. Städtisches Klinikum Nürnberg, Serologisches Institut, Flurstraße 17, D-8500, Nürnberg

    J. Abb

  2. Klinikum Großhadern, Medizinische Poliklinik A, Marchioninistraße 15, D-8000, München 70

    R. Zachoval

  3. Max-von-Pettenkofer-Institut, Pettenkoferstraße 9a, D-8000, München 2

    Vera Zachoval &  F. Deinhardt

Authors
  1. J. Abb
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  2. R. Zachoval
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  3. Vera Zachoval
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  4. F. Deinhardt
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Abb, J., Zachoval, R., Zachoval, V. et al. HIV antigen, HIV antibody and serum interferon in a patient with encephalopathy. Infection 15, 425–426 (1987). https://doi.org/10.1007/BF01647221

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  • DOI: https://doi.org/10.1007/BF01647221

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