Summary
Sisomicin, a new aminoglycoside similar to gentamicin, was administered parenterally to 20 patients who had complicated urinary tract infections. The infecting organisms were Proteus mirabilis, Escherichia coli, Pseudomonas aeruginosa, or Enterobacter, previously resistant to other antimicrobial medications. A 95 % cure rate was achieved; one patient responded to a second course of sisomicin, and overall there were no untoward side effects. This new antibiotic, which has the same spectrum and toxicity as gentamicin, appears to have greater efficacy.
Zusammenfassung
Sisomicin, ein dem Gentamicin ähnliches Aminoglykosid-Antibiotikum, wurde 20 Patienten, die an komplizierten Harnwegsinfektionen litten, parenteral verabreicht. Proteus mirabilis, Escherichia coli, Pseudomonas aeruginosa oder Enterobacter waren die infizierenden Keime; sie hatten auf eine vorhergehende antibakterielle Behandlung nicht angesprochen. Die Heilungsrate betrug 95 %; ein Patient reagierte auf eine zweite Behandlung mit Sisomicin. Unerwartete Begleiterscheinungen wurden nicht beobachtet. Das neue Antibiotikum, das das gleiche Spektrum und die gleiche Toxizität besitzt wie Gentamicin, scheint wirksamer zu sein.
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Boxer, R., Ehrlich, R. & Winters, R. Treatment of complicated urinary tract infections with sisomicin. Infection 4 (Suppl 4), S483–S484 (1976). https://doi.org/10.1007/BF01646988
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DOI: https://doi.org/10.1007/BF01646988