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Wirkungsvergleich von Sisomicin und Gentamicin im Tierexperiment

Comparison of the activity of sisomicin and gentamicin in mice protection studies

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Zusammenfassung

Die antibakterielle In-vivo-Aktivität von Sisomicin wurde vergleichend zu Gentamicin an weißen CF1-Mäusen geprüft (mice protection test). Die Tiere wurden mit verschiedenen bakteriellen Erregern (E. coli, Proteus spp., Klebsiella pneumoniae, Serratia marcescens, Pseudomonas aeruginosa, Staph. aureus) infiziert und anschließend mit Sisomicin bzw. Gentamicin behandelt. Die Ergebnisse zeigen, daß Sisomicin im Durchschnitt um den folgenden Faktor wirksamer als Gentamicin ist: bei Infektionen mit Serratia marcescens 1,3, Proteus spp. 1,9, E. coli 2,0, Klebsiella pneumoniae 2,4, Staph. aureus 2,5 und Pseudomonas aeruginosa 3,2.

Summary

The antibacterial in-vivo-activity of sisomicin in white CF1 mice was tested in comparison to gentamicin (mice protection test). The animals were infected with various bacterial strains (E. coli, Proteus spp., Klebsiella pneumoniae, Serratia marcescens, Pseudomonas aeruginosa, Staph. aureus), and then treated with sisomicin or gentamicin respectively. The results show that sisomicin is on the average more efficient than gentamicin by the following factors: against Serratia marcescens 1.3, Proteus spp. 1.9, E. coli 2.0, Klebsiella pneumoniae 2.4, Staph. aureus 2.5 and Pseudomonas aeruginosa 3.2.

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Authors and Affiliations

  1. Institut für Chemotherapie, Bayer AG, Postfach 13 01 05, D-5600, Wuppertal 1

    M. Scheer

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  1. M. Scheer
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Diese Publikation wurde auszugsweise auf dem 9. Internationalen Chemotherapie-Kongreß in London 1975 vorgetragen.

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Scheer, M. Wirkungsvergleich von Sisomicin und Gentamicin im Tierexperiment. Infection 4 (Suppl 4), S366–S369 (1976). https://doi.org/10.1007/BF01646966

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  • DOI: https://doi.org/10.1007/BF01646966

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