Summary
Sisomicin, gentamicin and tobramycin were tested in vitro against 25 isolates each of five genera of clinically significant gram-negative bacteria. Both minimal inhibitory concentrations and minimal bactericidal concentrations were determined using Mueller-Hinton broth and agar. In terms of inhibition, sisomicin was the most active drug against Enterobacter aerogenes, Klebsiella pneumoniae, Serratia marcescens and Proteus mirabilis, while tobramycin was the most active against Pseudomonas aeruginosa. In terms of bactericidal activity, sisomicin was the more active drug against E. aerogenes, K. pneumoniae and P. mirabilis, while gentamicin was the most active against S. marcescens and tobramycin the most active against P. aeruginosa.
Zusammenfassung
Sisomicin, Gentamicin und Tobramycin wurden in vitro gegen 25 Stämme von je fünf klinisch isolierten gramnegativen Bakterienarten getestet. MHK- und MBK-Werte auf Mueller-Hinton Nährboden und -agar wurden bestimmt. In seiner Hemmwirkung war Sisomicin das wirksamste Antibiotikum gegen Enterobacter aerogenes, Klebsiella pneumoniae, Serratia marcescens und Proteus mirabilis, während Tobramycin am wirksamsten gegen Pseudomonas aeruginosa war. In der bakteriziden Wirkung war Sisomicin das wirksamste Antibiotikum gegen Enterobacter aerogenes, Klebsiella pneumoniae und Proteus mirabilis, während Gentamicin am wirksamsten gegen Serratia marcescens und Tobramycin am wirksamsten gegen Pseudomonas aeruginosa war.
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Shadomy, S., Utz, C. & Wagner, G. In vitro studies with sisomicin, gentamicin and tobramycin. Infection 4 (Suppl 4), S305–S308 (1976). https://doi.org/10.1007/BF01646956
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DOI: https://doi.org/10.1007/BF01646956