Zusammenfassung
Die In-vitro-Wirksamkeit von Sisomicin, Gentamicin und Tobramycin wurde an insgesamt 492 Isolaten von Staph. aureus, Koagulase-negativen Staphylokokken, E. coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Indol-positiven Proteus spp., Proteus inconstans (Providencia) und Pseudomonas aeruginosa verglichen. Eine signifikant bessere Wirksamkeit ergab sich für Sisomicin gegenüber Staphylokokken, Klebsiella und Serratia. Gentamicin und Sisomicin waren wirksamer als Tobramycin gegenüber E. coli. Tobramycin war Gentamicin und Sisomicin signifikant überlegen gegenüber Pseudomonas. 25 % der grammegativen Isolate waren hochresistente Hospitalstämme, von denen wiederum sechs (= 1,5 %) wenigstens durch ein oder zwei der getesteten Aminoglykoside erfaßt wurden. Von diesen waren Klebsiella und Serratia Sisomicin- und Gentamicin-empfindlich, jedoch Tobramycin-resistent, während sich zwei Pseudomonasstämme als Tobramycin-empfindlich und Sisomicin-wie Gentamicin-resistent erwiesen.
Summary
The in vitro activity of sisomicin, gentamicin and tobramycin was compared in a total of 492 strains of Staph. aureus, coagulase negative staphylococci, E.coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, indole positive Proteus spp., Proteus inconstans (Providencia) und Pseudomonas aeruginosa. Against Staphylococci, Klebsiella and Serratia activity of sisomicin was significantly higher. Gentamicin and sisomicin were more effective than tobramycin against E. coli. Tobramycin was significantly more effective than gentamicin and sisomicin against Pseudomonas. 25% of the isolated bacteria were highly resistant nosocomial strains. Among these six (= 1.5 %) could be inhibited by one or two of the tested aminoglycosides, Klebsiella and Serratia being sensitive to sisomicin and gentamicin but resistant to tobramycin. Two Pseudomonas strains were sensitive to tobramycin but resistant to sisomicin and gentamicin.
This is a preview of subscription content, log in via an institution to check access.
Literatur
Buchanan, R. E., Gibbons, N. E. (eds.): Bergey's Manual of Determinative Bacteriology, 8th Ed. Williams and Wilkins Co., Baltimore 1974.
Cowan, S. T. Cowan and Steel's Manual for the Indentification of Medical Bacteria, 2nd Ed. Cambridge University Press, Cambridge 1974.
Crowe, C. C., Sanders, E. Sisomicin: Evaluation in-vitro and comparison with gentamicin and tobramycin. Antimicrob. Agents. Chemother. 3 (1973) 24.
Edwards, P. R., Ewing, W. H. Identification of Enterobacteriaceae, Burgess Pub. Co., Minneapolis 1972.
Ericsson, H. M., Sherris, J. C. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol. Microbiol. Scand. B 217 (1971) 1.
Hyams, P. J., Simberkoff, M. S., Rahal, J. J. In-vitro bactericidal effectiveness of four aminoglycoside antibiotics. Antimicrob. Agents Chemother. 3 (1973) 87.
Kawaguchi, H. H., Naito, T., Nakagawa, S., Fujisawa, K. BB-K8, a new semisynthetic aminoglycoside antibiotic. J. Antibiot. 25 (1972) 695.
Klastersky, J., Henri, A., Hensgens, C., Vandenborre, L., Daneau, D. Antipseudomonal drugs: Comparative study of gentymicin, sisomicin and tobramycin in-vitro and in human volunteers. Eur. J. Cancer 9 (1973) 641.
Klastersky, J., Nyamubeya, B., Vandenborre, L. Antimicrobial effectiveness of kanamycin, aminosidin, BB-K8, sisomicin, gentamicin and tobramycin combined with carbenicillin or cephalothin against gramnegative rods. J. Med. Microbiol. 7 (1974) 465.
Levison, M. E., Kaye, D. In-vitro comparison of four aminoglycoside antibiotics: sisomicin, gentamicin, tobramycin, and BB-K8. Antimicrob. Agents Chemother. 5 (1974) 667.
O'Hara, K., Kono, M., Mitsuhashi, S. Enzymatic inactivation of a new aminoglycoside antibiotic, sisomicin, by resistant strains of Pseudomonas aeruginosa, Antimicrob. Agents Chemother 5. (1974) 558.
Stark, W. M., Hoehn, M. M., Knox, N. G.: Nebramycin, a new broad-spectrum antibiotic complex. I. Detection and biosynthesis. Antimicrob. Agents Chemother. (1967) 314.
Stewart, D., Bodey, G. P. In-vitro activity of sisomicin, an aminoglycoside antibiotic, against clinical isolates. Antimicrob. Agents Chemother. 2 (1972) 431.
Waitz, J. A., Moss, E. L., Oden, E. M., Weinstein, M. J. Biological studies with antibiotic 6640, a new broad-spectrum aminoglycoside antibiotic. J. Antibiot. 23 (1970) 559.
Waitz, J. A., Moss, E. L., Drube, C. G., Weinstein, M. J. Comparative activity of sisomicin, gentamicin, kanamycin, and tobramycin. Antimicrob. Agents Chemother. 2 (1972) 431.
Watanakunakorn, C., Bannister, T. In-vitro activity of tobramycin and gentamicin against Enterobacteriaceae and gentamicinresistant, carbenicillin-resistant Pseudomonas aeruginosa. Curr. Ther. Res. 17 (1975) 488.
Weinstein, M. J., Marquez, J. A., Testa, R. T., Wagman, G. H., Oden, E. M., Waitz, J. A. Antibiotic 6640, a new Micromonospora-produced aminoglycoside antibiotic. J. Antibiot. 23 (1970) 551.
Welling, P. G., Mosegaard, A., Madsen, P. O. Sisomicin treatment of complicated urinary tract infections: Efficacy, tolerance and pharmacokinetics, J. Clin. Pharmacol. 14 (1974) 567.
Young, L. S., Hewitt, W. L. Activity of five aminoglycoside antibiotics in-vitro against gram-negative bacilli and Staphylococcus aureus. Antimicrob. Agents Chemother. 4 (1973) 617.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mauff, G., Schaal, K.P. & Pulverer, G. Vergleichende Untersuchungen zur In-vitro-Aktivität von Sisomicin, Gentamicin und Tobramycin. Infection 4 (Suppl 4), S300–S304 (1976). https://doi.org/10.1007/BF01646955
Issue Date:
DOI: https://doi.org/10.1007/BF01646955