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B-vitamins enhance afferent inhibitory controls of nociceptive neurons in the rat spinal cord

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Summary

Afferent inhibition of spinal dorsal horn neuronal responses to noxious skin heating was induced by transcutaneous electrical nerve stimulation in pentobarbital-anesthetized rats. Pretreatment with B vitamins significantly enhanced this afferent inhibition, possibly due to an increase in the synthesis rate of inhibitory neurotransmitters in central neurones.

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Fu, Q.G., Sandkühler, J. & Zimmermann, M. B-vitamins enhance afferent inhibitory controls of nociceptive neurons in the rat spinal cord. Klin Wochenschr 68, 125–128 (1990). https://doi.org/10.1007/BF01646860

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