Summary
The frequency and clinical features of acute hepatitis B virus (HBV) infection with and without a hepatitis D virus (HDV) co-infection was investigated retrospectively in the Stockholm region during two different time periods, September 1977–October 1978 and November 1984–October 1986. Totally, 31/229 (14%) patients with acute HBV infection had a HDV co-infection. No change in the frequency of co-infections, 12% and 15%, respectively, was observed between the 1970s and 1980s. Among the 31 HDV co-infected patients 74% were intravenous drug addicts. Totally 23/66 (35%) intravenous drug addicts with acute HBV infection had HDV co-infection. Clinically a biphasic rise of the serum levels of alanine aminotransferase and bilirubin was noted among 63% of the HDV co-infected patients but only among 8% of the solely HBV infected patients (p<0.001). A clinically more severe hepatitis was seen significantly more often among the HDV co-infected patients than among the solely HBV infected.
Zusammenfassung
In einer retrospektiven Studie wurden Häufigkeit und klinische Verläufe der akuten B-Hepatitis mit und ohne Koinfektion durch Hepatitis D Virus (HDV) in der Region Stockholm während zwei verschiedener Zeitphasen, September 1977 bis Oktober 1978 und November 1984 bis Oktober 1986, untersucht. Eine HDV-Koinfektion war bei 31/229 Patienten mit akuter HBV-Infektion (14%) aufgetreten. Zwischen den 70er und 80er Jahren waren keine Unterschiede in der Häufigkeit der Koinfektionen, die bei 12% und 15% lagen, festzustellen. 74% der 31 zusätzlich mit HDV infizierten Patienten waren i. v. Drogenabhängige. Insgesamt hatten 23/66 i. v. Drogenabhängigen (35%), die an einer akuten HBV-Infektion erkrankt waren, eine HDV-Koinfektion. Bei 63% der zusätzlich mit HDV infizierten Patienten war ein zweiphasischer Anstieg von Alanin Aminotransferase und Bilirubin im Serum zu beobachten; dies war nur bei 8% der nur mit HBV Infizierten der Fall (p<0,001). Ein schwerer klinischer Verlauf der Hepatitis fand sich bei Patienten mit HDV-Koinfektion signifikant häufiger als bei Kranken, die nur durch HBV infiziert waren.
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Lindh, G., Mattsson, L., von Sydow, M. et al. Acute hepatitis B and hepatitis D co-infection in the Stockholm region in the 1970s and 1980s — A comparison. Infection 18, 357–360 (1990). https://doi.org/10.1007/BF01646405
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DOI: https://doi.org/10.1007/BF01646405