Summary
Mecillinam was combined with ampicillin, carbenicillin, cloxacillin, and cefalexin and tested in vitro against clinical isolates of gram-negative bacteria. Synergy was frequently found, but test medium and inoculum size affected the extent of synergy. No synergy was obtained for combinations between mecillinam and penicillins against β-lactamase-producingHaemophilus influenzae orNeisseria gonorrhoeae, while combinations of clavulanic acid and penicillins showed strong synergism. Strains resistant to mecillinam were cultured in vitro, but the development of resistance was slower for the combinations than for mecillinam itself.
Zusammenfassung
Kombinationen von Mecillinam mit Ampicillin, Carbenicillin, Cloxacillin und Cephalexin wurden auf ihre Aktivität in vitro gegen in der Klinik isolierte, gramnegative Keime geprüft. Eine synergistische Wirkung zwischen den Komponenten wurde oft gefunden, ihr Ausmaß wurde aber von Nährmedium und Größe der Einsaat beeinflußt. Kombinationen von Mecillinam und Penizillinen zeigten keinen synergistischen Effekt gegen β-Laktamase-produzierendeHaemophilus influenzae undNeisseria gonorrhoeae. Dagegen wurde bei diesen Keimen ein starker Synergismus zwischen Klavulansäure und Penizillinen gefunden. Stämme, die resistent gegenüber Mecillinam sind, konnten in vitro gezüchtet werden, aber ihre Resistenzentwicklung erwies sich für die Mecillinam-Kombinationen langsamer als für Mecillinam selbst.
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Sjöberg, B., Ekström, B., Forsgren, U. et al. Synergy of mecillinam and clavulanic acid with other beta-lactam antibiotics. Infection 6 (Suppl 1), S17–S23 (1978). https://doi.org/10.1007/BF01646058
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DOI: https://doi.org/10.1007/BF01646058