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A comparative study of polydioxanone (PDS®) and polyglactin 910 (Vicryl®) in colonic anastomoses in rats


The use of polyglactin 910 (Vicryl®) in colonic anastomoses is theoretically undesirable because its short dissolution time and multifilament structure may lead to local sepsis and anastomotic leakage. We have compared Vicryl with a newly introduced monofilament absorbable suture which has a longer dissolution time than Vicryl. In a study of 98 rat colonic anastomoses no difference was found in complication rates or cellular reaction to the suture material between Vicryl and polydioxanone (PDS®). The use of monofilament suture with longer dissolution time does not necessarily imply added security for colonic anastomoses.

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Andersen, E., Søndenaa, K. & Holter, J. A comparative study of polydioxanone (PDS®) and polyglactin 910 (Vicryl®) in colonic anastomoses in rats. Int J Colorect Dis 4, 251–254 (1989).

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