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Clinical superinfection in complicated urinary tract infections: Therapy with broad-spectrum beta-lactam antibiotics in urology

Klinische Superinfektionen bei komplizierten Harnwegsinfektionen. Behandlung mit Breitspektrum-Beta-Lactam-Antibiotika in der Urologie

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Summary

In Japan, new antibiotics under development are compared with conventional antibiotics in Phase III controlled studies. Since the patients' demographic data, dosage, treatment period, etc. are made as uniform as possible in these studies, the results obtained are suitable for evaluating the characteristics of the new antibiotics. Most patients developing clinical superinfections suffer from complicated urinary tract infections due to underlying diseases. In order to avoid clinical superinfections, clinicians have to try to eradicate or alleviate these underlying diseases. The predominant microorganisms that may cause clinical superinfections to develop following therapy with broad-spectrum beta-lactam antibiotics include enterococci,Pseudomonas aeruginosa, otherPseudomonas spp. and fungi. Enterococci may frequently be detected in patients with mixed infections and can easily be dealt with by changing the antibiotics.

Zusammenfassung

In kontrollierten Phase III-Studien werden derzeit in Japan neue, in der Entwicklung befindliche Antibiotika verglichen. Da auf eine möglichst weitgehende Übereinstimmung der demographischen Daten der Patienten, der Dosierung und Behandlungsdauer geachtet wurde, können die Ergebnisse der Studien zur Beurteilung der Eigenschaften der neuen Antibiotika herangezogen werden. Die meisten Patienten, bei denen klinische Superinfektionen auftreten, leiden an Krankheiten der Harnwege, auf die sich komplizierte Harnwegsinfektionen aufpfropfen. Die Beseitigung oder Besserung dieser Grundkrankheiten ist die Voraussetzung dafür, daß klinische Superinfektionen vermieden werden können. Unter den Mikroorganismen, die vorwiegend nach Behandlung mit Breitspektrum-Beta-Lactam-Antibiotika klinische Superinfektionen auslösen können, sind Enterokokken,Pseudomonas aeruginosa, Pseudomonas spp. und Pilze. Enterokokken finden sich häufig bei Patienten mit Mischinfektionen, sie sind durch Wechsel der Antibiotika leicht zu beseitigen.

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Authors and Affiliations

  1. Department of Urology, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, Japan

    J. Kumazawa

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Kumazawa, J. Clinical superinfection in complicated urinary tract infections: Therapy with broad-spectrum beta-lactam antibiotics in urology. Infection 13 (Suppl 1), S96–S99 (1985). https://doi.org/10.1007/BF01644227

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