Skip to main content
SpringerLink
Log in

Treatment and prevention of pertussis by antimicrobial agents (Part II)

Behandlung und Verhütung des Keuchhustens mittels Antibiotika

  • Review
  • Published:
Infection Aims and scope Submit manuscript

Summary

Suitable antimicrobials given during the catarrhal stage of whooping cough can attenuate the course of the disease. The efficacy of antibiotics administered prophylactically during the incubation period remains controversial but appears to be beneficial. Currently, erythromycin given for two weeks is the antibiotic of choice for pertussis. No treatment failures were observed with erythromycin estolate. Erythromycin ethylsuccinate and stearate must be given at high dosages (50–60 mg/kg/day) in order to achieve sufficient concentrations in the respiratory secretions. With ampicillin and amoxicillin treatment failures have been observed. The role of josamycin and co-trimoxazole in pertussis remains open.

Zusammenfassung

Geeignete Antibiotika können den Verlauf des Keuchhustens abschwächen, wenn sie während des Stadium catarrhale gegeben werden. Die Wirksamkeit einer prophylaktischen Antibiotikum-Gabe während der Inkubationszeit bleibt umstritten, scheint jedoch von Nutzen zu sein. Derzeit ist Erythromycin, für zwei Wochen gegeben, das Antibiotikum der Wahl. Bei Gabe von Erythromycin-Estolat sind keine Therapieversager beobachtet worden. Erythromycin-Äthylsuccinat und -Stearat müssen hoch dosiert werden (50–60 mg/kg/Tag), um ausreichende Konzentrationen in den Atemwegssekreten zu erzielen. Bei Gabe von Ampicillin und Amoxicillin sind Therapieversager beobachtet worden. Die Rolle von Josamycin und Co-trimoxazol beim Keuchhusten ist noch nicht geklärt.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature

  1. Lambert, H. Antimicrobial drugs in the treatment and prevention of pertussis. J. Antimicrob. Chemother. 5 (1979) 329–331.

    Google Scholar 

  2. Nelson, J. D. Antibiotic treatment of pertussis. Pediatrics 44 (1969) 474–476.

    Google Scholar 

  3. Hoppe, J. E., Haug, A.: Antimicrobial susceptibility ofBordetella pertussis. Infection, in press.

  4. Field, L. H., Parker, C. D. Antibiotic susceptibility testing ofBordetella pertussis. Am. J. Clin. Pathol. 74 (1980) 312–316.

    Google Scholar 

  5. Smith, B. R., Le Frock, J. L. Bronchial tree penetration of antibiotics. Chest 83 (1983) 904–908.

    Google Scholar 

  6. Trollfors, B. Whooping cough-aspects of pathogenesis and treatment. Acta Otolaryngol. (Stockh.) Suppl. 407 (1984) 33–39.

    Google Scholar 

  7. Bass, J. W. Pertussis: current status of prevention and treatment. Pediatr. Infect. Dis. 4 (1985) 614–619.

    Google Scholar 

  8. Kwantes, W., Joynson, D. H. M., Williams, W. O. Bordetella pertussis isolation in general practice: 1977–1979 whooping cough epidemic in West Glamorgan. J. Hyg. (Camb.) 90 (1983) 149–158.

    Google Scholar 

  9. Medical Research Council Treatment of whooping cough with antibiotics. Lancet I (1953) 1109–1112.

    Google Scholar 

  10. Adcock, K. J., Reddy, S., Okubadejo, O. A., Montefiore, D. Trimethoprim/sulphamethoxazole in pertussis: comparison with tetracycline. Arch. Dis. Child. 47 (1972) 311–313.

    Google Scholar 

  11. Bass, J. W., Klenk, E. L., Kotheimer, J. B., Linnemann, C. C., Smith, M. H. D. Antimicrobial treatment of pertussis. J. Pediatr. 75 (1969) 768–781.

    Google Scholar 

  12. Strangert, K. Comparison between the effect of chloramphenicol and ampicillin in whooping cough. Scand. J. Infect. Dis. 1 (1969) 67–70.

    Google Scholar 

  13. Bass, J. W. Erythromycin for treatment and prevention of pertussis. Pediatr. Infect. Dis. 5 (1986) 154–157.

    Google Scholar 

  14. Islur, J., Anglin, C. S., Middleton, P. J. The whooping cough syndrome: a continuing pediatric problem. Clin. Pediatr. 14 (1975) 171–176.

    Google Scholar 

  15. Henry, R. L., Dorman, D. C., Skinner, J. A., Mellis, C. M. Antimicrobial therapy in whooping cough. Med. J. Aust. 2 (1981) 27–28.

    Google Scholar 

  16. Trollfors, B. Effect of erythromycin and amoxycillin onBordetella pertussis in the nasopharynx. Infection 6 (1978) 228–230.

    Google Scholar 

  17. Baraff, L. J., Wilkins, J., Wehrle, P. F. The role of antibiotics, immunizations, and adenoviruses in pertussis. Pediatrics 61 (1978) 224–230.

    Google Scholar 

  18. Bergquist, S. O., Bernander, S., Dahnsjö, H., Sundelöf, B. Erythromycin in the treatment of pertussis: a study of bacteriologic and clinical effects. Pediatr. Infect. Dis. 6 (1987) 458–461.

    Google Scholar 

  19. Henry, R. L., Dorman, D. C., Skinner, J. A., Mellis, C. M. Limitations of erythromycin in whooping cough. Med. J. Aust. 2 (1981) 108–109.

    Google Scholar 

  20. McCracken, G. H., Ginsburg, C. M., Clahsen, J. C., Thomas, M. L. Pharmacologic evaluation of orally administered antibiotics in infants and children: effect of feeding on bioavailability. Pediatrics 62 (1975) 738–743.

    Google Scholar 

  21. Eriksson, M., Bolme, P., Blennow, M. Absorption of erythromycin from pediatric suspension in infants and children. Scand. J. Infect. Dis. 13 (1981) 211–215.

    Google Scholar 

  22. Halsey, N. A., Welling, M. A., Lehman, R. M. Nosocomial pertussis: a failure of erythromycin treatment and prophylaxis. Am. J. Dis. Child. 134 (1980) 521–522.

    Google Scholar 

  23. Ginsburg, C. M. Pharmacology of erythromycin in infants and children. Pediatr. Infect. Dis. 5 (1986) 124–129.

    Google Scholar 

  24. Dette, G. A. Vergleich der Gewebegängigkeit von Erythromycin. Infection 7 (1979) 129–145.

    Google Scholar 

  25. Eichenwald, H. F. Adverse reactions to erythromycin. Pediatr. Infect. Dis. 5 (1986) 147–150.

    Google Scholar 

  26. Broomhall, J., Herxheimer, A. Treatment of whooping cough: the facts. Arch. Dis. Child. 59 (1984) 185–187.

    Google Scholar 

  27. Altemeier, W. A., Ayoub, E. M. Erythromycin prophylaxis for pertussis. Pediatrics 59 (1977) 623–625.

    Google Scholar 

  28. Linnemann, C. C., Ramundo, N., Perlstein, P. H., Minton, S. D., Englender, G. S., McCormick, J. B., Hayes, P. S. Use of pertussis vaccine in an epidemic involving hospital staff. Lancet II (1975) 540–543.

    Google Scholar 

  29. Grob, P. R. Prophylactic erythromycin for whooping cough contacts. Lancet I (1981) 772.

    Google Scholar 

  30. Spencely, M., Lambert, H. P. Prophylactic erythromycin for whooping cough contacts. Lancet I (1981) 772–773.

    Google Scholar 

  31. Torre, D., Maggiolo, F., Sampietro, C. Comparative clinical study of josamycin and erythromycin in pertussis. Chemioterapia 3 (1984) 255–257.

    Google Scholar 

  32. Schreinert, B. Josamycin — ein neues Makrolid-Antibiotikum. Klinische Erfahrungen in der Pädiatrie. Extracta Medica Practica 6, Suppl. 1 (1985) 59–62.

    Google Scholar 

  33. Waßmer, B., Riedl-Seifert, R. Hals-Nasen-Ohren-Infekte bei älteren Kindern: ein Vergleich zwischen Josamycin und Erythromycin. Sozialpädiatrie 9 (1987) 89–90.

    Google Scholar 

  34. Cascio, G., Titone, L., Portelli, V., Castello, G. Josamycin bei Streptokokkeninfektionen und Pertussis. Extracta Paediatrica 8, Suppl. 1 (1984) 47–52.

    Google Scholar 

  35. Simon, C., Bontemps, M., Wiese, K., Schewior-Roland, R. Zur Ampicillin-Therapie des Keuchhustens. Dtsch. Med. Wochenschr. 94 (1969) 2435–2437.

    Google Scholar 

  36. Feigin, R. D. Pertussis (whooping cough). In:Nelson, W. E., Behrman, R. E., Vaughan, V. C. (eds.): Textbook of pediatrics. W. B. Saunders, Philadelphia 1983, pp. 658–661.

    Google Scholar 

  37. Hughes, D. T. D., Bye, A., Hodder, P. Levels of trimethoprim and sulphamethoxazole in blood and sputum in relation to treatment of chest infections. In:Hejzlar, M., Semonsky, M., Masak, S. (eds.): Advances in antimicrobial and antineoplastic chemotherapy I/2. Urban & Schwarzenberg, München 1972, pp. 1105–1106.

    Google Scholar 

  38. Cullen, A. S., Cullen, H. B. Whooping cough: prophylaxis with cotrimoxazole. Lancet I (1978) 556.

    Google Scholar 

  39. Arneil, G. C., McAllister, T. A. Whooping cough in infants: antimicrobial prophylaxis? Lancet II (1977) 33–34.

    Google Scholar 

  40. Arneil, G. C., McAllister, T. A. Prevention of whooping cough by antibiotics. Practitioner 219 (1977) 855–858.

    Google Scholar 

  41. Rabo, E. Drug prophylaxis in pertussis. Lancet II (1977) 707–708.

    Google Scholar 

  42. Nakazawa, S., Sato, H., Niino, K., Nakazawa, S. I., Suzuki, H., Iwasaki, A., Chikaoka, H., Hirama, Y., Narita, A. Treatment of pertussis with cefoperazone. Jap. J. Antibiot. 33 (1980) 865–870.

    Google Scholar 

  43. Motohiro, T., Sakata, Y., Fujimoto, T., Nishiyama, T., Nakajima, T., Ishimoto, K., Tominaga, K., Yamashita, F., Shishido, H., Watanabe, K., Matsumoto, K., Tazaki, K., Oki, S., Araki, H., Takajo, N., Yuasa, K., Tanaka, Y., Tsugawa, S., Nagayama, K., Komatsu, R., Yamamoto, M., Ookita, R., Sakaguchi, Y., Terasawa, K., Kinoshita, M. Treatment of whooping cough and whooping cough syndrome by cefoperazone. Jap. J. Antibiot. 33 (1980) 1183–1193.

    Google Scholar 

  44. Minamitani, M., Hachimori, K., Nakazawa, S., Sato, H., Narita, A., Hirama, Y., Nakazawa, S. I., Chikaoka, H., Motohiro, T., Nishiyama, T., Fujimoto, T., Ishimoto, K., Tominaga, K., Yamashita, F., Matsuo, H., Koga, Y., Eto, Y., Matsuyuki, M., Yuasa, T., Tanaka, Y., Nagayama, K., Shimada, Y., Aramaki, S., Takajo, N., Araki, H., Kowano, Y. Clinical results of latamoxef on pertussis. Jap. J. Antibiot. 36 (1983) 233–240.

    Google Scholar 

  45. Aufrant, C., Lambert-Zechovsky, N., Aujard, Y., Bingen, E., Blum, C., Beaufils, F., Mathieu, H. Le céfotaxime dans les infections à bacille Gram négatif de l'enfant. Nouv. Presse Méd. 10 (1981) 639–646.

    Google Scholar 

  46. Garnier, J. M., Giraud, F. Utilisation du céfotaxime dans les maladies infectieuses de l'enfant. Nouv. Presse Méd. 10 (1981) 629–633.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University Children's Hospital, Rümelinstr. 23, D-7400, Tübingen

    J. E. Hoppe & A. Haug

Authors
  1. J. E. Hoppe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Haug
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hoppe, J.E., Haug, A. Treatment and prevention of pertussis by antimicrobial agents (Part II). Infection 16, 148–152 (1988). https://doi.org/10.1007/BF01644089

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01644089

Keywords

Search

Navigation