Summary
Thein vitro activity of lomefloxacin, a new difluorinated quinolone, was compared to that of ciprofloxacin, ofloxacin, norfloxacin and other relevant antibacterial agents. Lomefloxacin and norfloxacin shared similar activity, whereas ofloxacin and in particular ciprofloxacin showed superior activity. Most gram-negative aerobes were susceptible to all four quinolones, 90% of isolates were inhibited by 1 mg/l. The gram-positive organisms were generally less susceptible, although 90% ofStaphylococcus aureus isolates were inhibited by 0.5 mg/l of ciprofloxacin and ofloxacin; values for lomefloxacin and norfloxacin were 1 mg/l and 2 mg/l, respectively; susceptibility was not affected by methicillin resistance.Neisseria gonorrhoeae andHaemophilus influenzae were highly susceptible to the quinolones, especially ciprofloxacin. Penicillin/ampicillin-resistant isolates remained susceptible to the quinolones.
Zusammenfassung
DieIn-vitro-Aktivität von Lomefloxacin, einem difluorierten Chinolon, wurde mit derjenigen von Ciprofloxacin, Ofloxacin, Norfloxacin und anderen klinisch wichtigen Antibiotika verglichen. Die Wirksamkeit von Lomefloxacin war mit der des Norfloxacin vergleichbar, während sich Ofloxacin und vor allem Ciprofloxacin als überlegen erwiesen. Die meisten gramnegativen Aerobier waren gegen alle vier Chinolone empfindlich; 90% der Isolate wurden bei 1 mg/l gehemmt. Grampositive Erreger waren allgemein weniger empfindlich; doch wurden 90% der Stämme vonStaphylococcus aureus durch Ciprofloxacin und Ofloxacin in einer Konzentration von 0,5 mg/l gehemmt; die MHK90-Werte von Lomefloxacin und Norfloxacin betrugen 1 mg/l bzw. 2 mg/l. Methicillin-Resistenz hatte keinen Einfluß auf die Empfindlichkeit.Neisseria gonorrhoeae undHaemophilus influenzae erwiesen sich als hochempfindlich gegenüber den Chinolonen, vor allem gegen Ciprofloxacin. Bei Resistenz gegen Penicillin oder Ampicillin blieb die Empfindlichkeit gegen die Chinolone erhalten.
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Sun, Z.M., Maskell, J.P., Williams, J.D. et al. In-vitro activity of lomefloxacin (SC-47111) and other quinolones. Infection 17, 165–167 (1989). https://doi.org/10.1007/BF01644019
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DOI: https://doi.org/10.1007/BF01644019