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MICs of ciprofloxacin and trimethoprim for Escherichia coli: Influence of pH, inoculum size and various body fluids

Minimale Hemmkonzentrationen von Ciprofloxacin und Trimethoprim gegen Escherichia coli: Einfluß von pH, Inokulungröße und verschiedenen Körperflüssigkeiten

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Summary

The influence of pH, inoculum size, human urine and prostatic extract on the MICs of ciprofloxacin and trimethoprim forEscherichia coli was investigated. There was no influence by the bacterial inoculum size within wide ranges on either drug. An increase in pH had a variable influence on the MICs of trimethoprim forE. coli but lowered those of ciprofloxacin considerably. Human prostatic extract increased the trimethoprim MIC forE. coli but lowered those of ciprofloxacin as compared to Mueller Hinton broth. Human urine increased the MICs of both drugs forE. coli.

Zusammenfassung

Der Einfluß von pH, Inokulumgröße, menschlichem Urin und Prostataextrakt auf die minimalen Hemmkonzentrationen von Ciprofloxacin und Trimethoprim gegenEscherichia coli wurde untersucht. Für keines der beiden Antibiotika ergab sich ein Einfluß der in einem großen Bereich geprüften Inokulumgrößen. Bei ansteigendem pH-Wert zeigten sich für Trimethoprim wechselnde Veränderungen der minimalen Hemmkonzentrationen gegenE. coli, die MHK-Werte für Ciprofloxacin wurden dagegen erheblich erniedrigt. Bei Prüfung in menschlichem Prostataextrakt waren die Trimethoprim-MHK-Werte gegenE. coli höher, die Werte für Ciprofloxacin dagegen niedriger als in Mueller-Hinton Bouillon. In menschlichem Urin zeigten sich für beide Antibiotika erhöhte MHK-Werte gegenE. coli.

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Authors and Affiliations

  1. Urology Service, USA

    J. Aagaard M.D. (Research Fellow)

  2. Lab. Tech., Willism S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, 53705, Madison, WI, USA

    P. O. Madsen M. D., Ph. D. (Chief) & P. Rhodes

  3. Urologie Abteilung, Kantonspital Basel, CH-Basel, Switzerland

    T. Gasser M.D.

Authors
  1. J. Aagaard M.D.
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  2. P. O. Madsen M. D., Ph. D.
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  3. P. Rhodes
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  4. T. Gasser M.D.
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Aagaard, J., Madsen, P.O., Rhodes, P. et al. MICs of ciprofloxacin and trimethoprim for Escherichia coli: Influence of pH, inoculum size and various body fluids. Infection 19 (Suppl 3), S167–S169 (1991). https://doi.org/10.1007/BF01643691

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  • DOI: https://doi.org/10.1007/BF01643691

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