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Cerebrospinal fluid and serum neopterin levels in patients with Lyme neuroborreliosis

Neopterin-Liquor- und Serumspiegel bei Patienten mit Lyme Neuroborreliose

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Summary

Elevated (>3.0 nmol/l) cerebrospinal fluid neopterin concentrations were observed in 20 of 21 patients with Lyme neuroborreliosis compared with three of 11 control patients with headache, back pain or psychoneurotic disorders. Neopterin concentrations were correlated to mononuclear cell counts and protein concentrations in the cerebrospinal fluid (CSF). Following antibiotic treatment, CSF neopterin levels decreased. Serum neopterin levels were not significantly raised in patients with neuroborreliosis when compared to control subjects. Neopterin levels as well as cell count and protein concentration in the CSF are valuable inflammation markers of disease activity in Lyme neuroborreliosis.

Zusammenfassung

Bei 20 von 21 Patienten mit Lyme Neuroborreliose fanden sich erhöhte Spiegel (>3,0 nMol/l) von Neopterin im Liquor; bei Patienten mit Kopfschmerzen, Rückenschmerzen oder neurotischen Störungen war dies nur in drei von elf Fällen nachzuweisen. Es bestand eine Korrelation zwischen dem Liquorgehalt an mononukleären Zellen und Eiweiß. Nach Antibiotikatherapie gingen die Neopterinspiegel zurück. Im Vergleich zu den Kontrollpersonen war bei den Patienten mit Neuroborreliose keine signifikante Erhöhung der Neopterinspiegel im Serum festzustellen. Die Neopterinspiegel im Liquor sind neben den Zellzahlen und der Eiweißkonzentration wertvolle unspezifische Entzündungsmarker und Parameter für die Krankheitsaktivität bei Neuroborreliose.

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Authors and Affiliations

  1. Department of Infectious Diseases, University of Göteborg, S-416 85, Göteborg, Sweden

    L. Dotevall M. D. & L. Hagberg M. D.

  2. Institute of Medical Chemistry and Biochemistry University of Innsbruck, Fritz-Pregl-Str. 3, A-6020, Innsbruck, Austria

    D. Fuchs Ph. D., G. Reibnegger D. Sc. & H. Wachter Ph. D.

Authors
  1. L. Dotevall M. D.
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  2. L. Hagberg M. D.
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  3. D. Fuchs Ph. D.
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  4. G. Reibnegger D. Sc.
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  5. H. Wachter Ph. D.
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Dotevall, L., Hagberg, L., Fuchs, D. et al. Cerebrospinal fluid and serum neopterin levels in patients with Lyme neuroborreliosis. Infection 18, 210–214 (1990). https://doi.org/10.1007/BF01643387

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  • DOI: https://doi.org/10.1007/BF01643387

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