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Tobramycin-Konzentrationen im humanen Nierengewebe

Tobramycin concentrations in human renal tissue

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Zusammenfassung

Untersuchungen an Nieren von 20 Patienten wiesen Tobramycinkonzentrationen in Rinde und Mark auf, die nach eintägiger Behandlung verhältnismäßig niedrig lagen. Eine deutliche Akkumulation nach Applikation über mehrere Tage fand sich nur in einem von drei Fällen. Hinzuweisen ist auf die höheren Tobramycinkonzentrationen in chronisch-entzündlich verändertem Nierenparenchym gegenüber den „normalen“ Anteilen von tumorinfiltrierten Nieren. Eine stärkere Akkumulation findet somit in Nierengeweben statt, die durch bakterielle Entzündungen bereits deutlich strukturgeschädigt sind.

Summary

Investigation of kidneys from 20 patients revealed relatively low tobramycin concentrations in cortex and medulla after one day of treatment. After administration for several days a significant accumulation was observed in only one of three patients. Attention is drawn to the higher tobramycin concentrations found in renal parenchyma which has undergone chronic inflammatory changes compared to the ”normal“ values in kidneys infiltrated by tumours. A higher accumulation thus occurs in renal tissue which has already undergone structural damage as a result of bacterial inflammation.

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Authors and Affiliations

  1. Abteilung für Innere Medizin im Klinikum Westend der Freien Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19

    O. Brückner

  2. Zentrallaboratorium der Lungenklinik Heckeshorn des Krankenhauses Zehlendorf, Am Großen Wannsee 80, D-1000, Berlin 39

    U. Kroening

  3. Urologische Abteilung im Klinikum Westend der Freien Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, West Germany

    R. Nagel

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  1. O. Brückner
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  2. U. Kroening
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Brückner, O., Kroening, U. & Nagel, R. Tobramycin-Konzentrationen im humanen Nierengewebe. Infection 7, 283–289 (1979). https://doi.org/10.1007/BF01642150

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