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Comparison of mezlocillin, piperacillin, bay k 4999 with carbenicillin and ticarcillin against Enterobacteriaceae and Pseudomonas aeruginosa

Vergleich der In-vitro-Aktivität von Bay k 4999 mit Mezlocillin, Piperacillin und anderen Beta-Lactamantibiotika gegen Enterobacteriaceae und Pseudomonas aeruginosa

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Summary

The minimal inhibitory concentration (MIC) of five penicillins (carbenicillin, ticarcillin, mezlocillin, piperacillin and Bay k 4999) againstEscherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, indole positiveProteus sp. andEnterobacter species was determined by an agar dilution method. Bay k 4999 and piperacillin were found to be the most active of the semi-synthetic penicillins tested againstP. aeruginosa andEnterobacteriaceae. Bay k 4999 was slightly more active than piperacillin againstE. coli, about as active as piperacillin againstPseudomonas, K. pneumoniae, P. mirabilis and indole positiveProteus, but more active than piperacillin againstEnterobacter species.

Zusammenfassung

Die minimale Hemmkonzentration (MHK) von fünf Penicillinen (Carbenicillin, Ticarcillin, Mezlocillin, Piperacillin und Bay k 4999) gegenEscherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, indolpositiveProteus sp. undEnterobacter sp. wurde mit Agarverdünnungstest festgestellt. Bay k 4999 und Piperacillin erwiesen sich von den getesteten halbsynthetischen Penicillinen am wirksamsten gegenP. aeruginosa undEnterobacteriaceae. Bay k 4999 war gegenE. coli etwas wirksamer als Piperacillin, ebenso wirksam wie Piperacillin gegenPseudomonas, K. pneumoniae, P. mirabilis und indolpositiveProteus sp., aber aktiver als Piperacillin gegenEnterobacter species.

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Literature

  1. Bodey, G. P., Pan, T. Mezlocillin: In vitro studies of a new broadspectrum penicillin. Antimicrob. Agents Chemother. 11 (1977) 74–79.

    Google Scholar 

  2. Fu, K. P., Neu, H. C. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob. Agents Chemother. 13 (1978) 358–367.

    Google Scholar 

  3. Steers, E., Foltz, E. L., Graves, B. S., Rider, J. An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics. Antibiot. Chemother. 9 (1959) 307–311.

    Google Scholar 

  4. Wise, R., Andrews, J. M., Bedford, K. A. Comparison of the in vitro activity of Bay k 4999 and piperacillin, two new anti-pseudomonal broad-spectrum penicillins, with other β-lactam drugs. Antimicrob. Agents Chemother. 14 (1978) 549–552.

    Google Scholar 

  5. Wise, R., Cadge, B., Gillett, A. P., Bhamjee, A., Livingston, R., Welling, P. G., Thornhill, D. P. Pharmacokinetics of Bay k 4999, a new broad-spectrum penicillin. Antimicrob. Agents Chemother. 15 (1979) 670–673.

    Google Scholar 

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Authors and Affiliations

  1. 177 A Derech Hayam, Haifa, Israel

    J. D. Sobel

  2. The Medical College of Pennsylvania, 3300 Henry Avenue, 19129, Philadelphia, Pennsylvania, USA

    M. E. Levison &  D. Kaye

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  1. J. D. Sobel
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  2. M. E. Levison
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  3. D. Kaye
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Sobel, J.D., Levison, M.E. & Kaye, D. Comparison of mezlocillin, piperacillin, bay k 4999 with carbenicillin and ticarcillin against Enterobacteriaceae and Pseudomonas aeruginosa. Infection 8, 121–122 (1980). https://doi.org/10.1007/BF01641477

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  • DOI: https://doi.org/10.1007/BF01641477

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