Summary
We have reviewed 38 patients with brucellosis who were admitted to the Chaim Sheba Medical Center between 1955 and 1977, i. e. during a 23-year period. The clinical manifestations varied greatly. Diagnosis was easy when brucellosis was suspected, as in cases presenting with fever of unknown origin. In nine of the 38 cases diagnosis was difficult and delayed for several weeks since brucellosis was not suspected. Some of these cases will be described in detail. The diagnosis was established in 16 patients by isolatingBrucella melitensis and in the other 22 by serological tests. There were no relapses in the 26 patients treated with a combination of streptomycin and tetracycline; two of the 12 patients treated with tetracycline alone relapsed. Brucellosis should be considered when clinical manifestations are puzzling.
Zusammenfassung
Wir berichten über eine retrospektive Analyse von 38 Patienten mit Bruzellose, die während eines Zeitraums von 23 Jahren, von 1955 bis 1977, im Chaim Sheba Medical Center stationärbehandelt wurden. Das klinische Erscheinungsbild war sehr wechselhaft. Die Diagnose war leicht zu stellen. wenn, wie in Fällen von unklarem Fieber, Bruzellose vermutet wurde. In neun von 38 Fällen war die Diagnose schwierig und wurde erst mit mehrwöchiger Verzögerung gestellt, da die Erkrankung nicht erwogen wurde. Einige dieser Fälle werden detailliert beschrieben. Bei 16 Patienten wurde die Diagnose durch die Isolation vonBrucella melitensis, bei den übrigen 22 durch serologische Tests erhärtet. Bei 26 Patienten, die mit einer Kombination von Streptomycin und Tetracyclin behandelt wurden, traten keine Rezidive auf Hingegen erlitten zwei der 12 Patienten, die nur mit Tetracyclin behandelt wurden, Rückfälle. Bei unklarem klinischem Bild sollte an Bruzellose gedacht werden.
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Samra, Y., Shaked, Y., Hertz, M. et al. Brucellosis: Difficulties in diagnosis and a report on 38 cases. Infection 11, 310–312 (1983). https://doi.org/10.1007/BF01641353
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DOI: https://doi.org/10.1007/BF01641353