Summary
Mild and severe experimental ocular infections in rabbits' eyes were induced by inoculation of Candida albicans with or without addition of dexamycin drops. These rabbits were treated with 5-Fluorocytosine, topically, orally and in a combined topical and oral manner. The topical treatment was effective only in mild infections. Severe infections responded to oral and especially to combined oral-topical treatment.
Zusammenfassung
An Kaninchenaugen wurden leichte und schwere Augeninfektionen experimentell durch Beimpfung mit Candida albicans mit oder ohne Zusatz von Dexamycin-Tropfen hervorgerufen. Diese Kaninchen wurden lokal, oral und kombiniert lokal-oral mit 5-Fluorzytosin behandelt. Die lokale Wirkung war lediglich bei leichten Infektionen wirksam. Schwere Infektionen sprachen auf orale und insbesondere auf die kombinierte oral-lokale Behandlung an.
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Segal, E., Eylan, E., Romano, A. et al. Experimental and clinical studies of 5-Fluorocytosine activity in candida ocular infections. Infection 3, 165–168 (1975). https://doi.org/10.1007/BF01641341
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DOI: https://doi.org/10.1007/BF01641341