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Antistaphylococcal activity of sisomicin and four other aminoglycosides against strains sensitive and resistant to methicillin

Staphylokokkenabtötende Wirkung von Sisomicin und weiteren vier Aminoglykosiden gegenüber Methicillin-empfindlichen und Methicillin-resistenten Stämmen

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Summary

Five aminoglycosides were tested for inhibitory activity on 91 strains of Staphylococcus aureus, 39 of which were methicillin-resistant. The antistaphylococcal activity of these antibiotics was independent of the methicillin-resistance. Their order of decreasing effectiveness was: gentamicin > tobramycin=sisomicin > amikacin > kanamycin. Resistant strains were only found for the latter.

Zusammenfassung

Fünf Aminoglykoside wurden hinsichtlich ihrer Hemmwirkung an 91 Stämmen von Staph. aureus geprüft, wovon 39 Methicillin-resistent waren. Die staphylokokkentötende Wirkung dieser Antibiotika war von der Methicillin-Resistenz unabhängig. Ihre Wirksamkeit nahm in folgender Reihenfolge ab: Gentamicin > Tobramycin=Sisomycin > Amikacin > Kanamycin. Resistente Stämme fanden sich nur bei dem letztgenannten Antibiotikum.

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Authors and Affiliations

  1. Service de Biologie Clinique, Hôpital Universitaire Brugmann, Avenue J.-J. Crocq 1, B-1020, Bruxelles, Belgium

    E. Yourassowsky,  E. Schoutens &  M. P. Vanderlinden

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  1. E. Yourassowsky
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  2. E. Schoutens
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  3. M. P. Vanderlinden
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Yourassowsky, E., Schoutens, E. & Vanderlinden, M.P. Antistaphylococcal activity of sisomicin and four other aminoglycosides against strains sensitive and resistant to methicillin. Infection 3, 148–149 (1975). https://doi.org/10.1007/BF01641337

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  • DOI: https://doi.org/10.1007/BF01641337

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