Summary
Bestatin, a new immunomodulator which is chemically well-defined, was examined for its capacity to enhance the phagocytic activity of neutrophilic granulocytes from patients with furunculosis. The ability of the granulocytes to ingest fluorescein-labelled yeast particles was significantly decreased in 19 patients with recurrent furunculosis (p<0.01). Oral administration of 40 mg bestatin to ten patients increased the phagocytic function of their granulocytes significantly (p<0.01).
Zusammenfassung
Bestatin, ein neuer, chemisch definierter Immunmodulator, wurde auf seine Fähigkeit zur Verstärkung der Phagozytoseaktivität neutrophiler Granulozyten von Patienten mit Furunkulose geprüft. Bei 19 Patienten mit rezidivierender Furunkulose war die Fähigkeit der Granulozyten zur Aufnahme Fluoresceinmarkierter Hefepartikel signifikant verändert (p<0,01). Zehn Patienten wurden mit 40 mg Bestatin oral behandelt; daraufhin nahm die Phagozytosefunktion ihrer Granulozyten signifikant zu (p<0,01).
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Mattsson, L., Blomgren, H., Holmgren, B. et al. Bestatin treatment for the correction of granulocyte dysfunction in patients with recurrent furunculosis. Infection 11, 205–207 (1983). https://doi.org/10.1007/BF01641198
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DOI: https://doi.org/10.1007/BF01641198