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Ventriculitis, aqueductal stenosis and hydrocephalus in neonatal meningitis: Diagnose and treatment

Ventriculitis, Stenose des Aquaeductus cerebri und Hydrocephalus bei neonataler Meningitis. Diagnose und Therapie


Five newborns are presented who had meningitis and developed aqueductal stenosis. The diagnosis of obstruction was made by ventriculography during the course of meningitis. A variety of therapeutic measures (use of intraventricular antibiotics, use of reliably diffusible antibiotics, drainage of ventricles) led to varying results. Protocols should be established to assess each modality or combination thereof to help reduce the extremely high morbidity and mortality of this disease.


Es wird über fünf Neugeborene mit Meningitis berichtet, die eine Stenose des Aquaeductes cerebri entwickelten. Die Diagnose der Obstruktion wurde im Verlauf der Meningitis durch Ventrikulographie erhoben. Eine Vielzahl therapeutischer Maßnahmen (Anwendung intraventrikulärer sowie zuverlässig diffusionsfähiger Antibiotika, Ventrikeldränage) führte zu unterschiedlichen Ergebnissen. Zur Beurteilung jeder Behandlungsmodalität oder Kombinationstherapie sollten Protokolle erstellt werden, um zu einer Verringerung der extrem hohen Morbidität und Mortalität dieser Krankheit beizutragen.

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  1. 1.

    Overall, J. C. Neonatal bacterial meningitis. Analysis of pre-disposing factors and outcome compared with matched controlled subjects. J. Pediatr. 76 (1970) 499–511.

    Google Scholar 

  2. 2.

    Berman, P. H., Banker, B. Q. Neonatal meningitis: A clinical and pathological study of 29 cases. Pediatrics 38 (1966) 6–24.

    Google Scholar 

  3. 3.

    Matson, D. D. Neurosurgery of infancy and childhood, p. 203. Charles C. Thomas, Springfield, Ill. 1969.

    Google Scholar 

  4. 4.

    Chang, M. J., Escobedo, M., Anderson, D. C., Hillman, L., Feigin, R. D. Kenamycin and gentamicin in treatment of neonatal sepsis and meningitis. Pediatrics 56 (1975) 695–699.

    Google Scholar 

  5. 5.

    Rieselbach, R. E. Subarachnoid distribution of drugs after lumbar injection. N. Engl. J. Med. 267 (1962) 1273–1278.

    Google Scholar 

  6. 6.

    Moellering, R. C., Fischer, E. G. Relation of intraventricular gentamicin levels to cure meningitis. J. Pediatr. 81 (1972) 534–537.

    Google Scholar 

  7. 7.

    Salmon, J. H. Ventriculitis complicating meningitis. Am. J. Dis. Child. 124 (1972) 34–40.

    Google Scholar 

  8. 8.

    Ennis, F. A. Hydrocephalus in hamsters: Induction by natural and attenuated mumps viruses. J. Infect. Dis. 119 (1969) 75–79.

    Google Scholar 

  9. 9.

    Johnson, R. T., Johnson, K. P. Hydrocephalus as a sequela of experimental myxovirus infections. Exp. Mol. Pathol. 10 (1969) 68–80.

    Google Scholar 

  10. 10.

    Johnson, R. T., Johnson, K. P. Hydrocephalus following viral infection. The pathology of aqueductal stenosis developing after experimental mumps virus. J. Neuropathol. Exp. Neurol. 27 (1968) 591–606.

    Google Scholar 

  11. 11.

    Noetzel, H. Stenosis or atresia of the aqueduct of sylvius as a cause of congenital hydrocephalus. Dev. Med. Child. Neurol. 22 Suppl. (1970) 123–126.

    Google Scholar 

  12. 12.

    Miller, L. H. Late onset of disease in congenital toxoplasmosis. Clin. Pediatr. (Phila) 10 (1971) 78–80.

    Google Scholar 

  13. 13.

    Timmons, G. D., Johnson, K. P. Aqueductal stenosis and hydrocephalus after mumps encephalitis. N. Engl. J. Med. 283 (1970) 1505–1507.

    Google Scholar 

  14. 14.

    Edwards, J. H. The syndrome of sex-linked hydrocephalus. Arch. Dis. Child. 36 (1961) 486–493.

    Google Scholar 

  15. 15.

    Shannon, M. W. X-linked hydrocephalus. J. Med. Genet. 5 (1968) 326–328.

    Google Scholar 

  16. 16.

    Sojid, M. H. Familial aqueductal stenosis and basilar inpression. Neurol. 18 (1968) 260–262.

    Google Scholar 

  17. 17.

    Nag, T. K.: Non-tumoral stenosis of the aqueduct in adults. Br. Med. J. (1966) 1168–1170.

  18. 18.

    Slager, U. T. Basic neuropathology, p. 241. The Williams and Wilkins Co., Baltimore 1970.

    Google Scholar 

  19. 19.

    Green, R. Remission of thyrotoxicosis and exophthalmos after drainage of aqueduct of sylvius. Br. Med. J. 3 (1968) 412–413.

    Google Scholar 

  20. 20.

    Williams, B. Is aqueductal stenosis a result of hydrocephalus? Brain 96 (1973) 399–412.

    Google Scholar 

  21. 21.

    Nelson, J. B.: Unpublished data.

  22. 22.

    McCracken, G. H., Charne, D. F., Thomas, M. L. Pharmacologic evaluation of gentamicin in newborn infants. J. Infect. Dis. 124 Suppl. (1971) 213–214.

    Google Scholar 

  23. 23.

    Klein, J. O., Herschel, M., Therakan, R. M., Ingall, D. Gentamicin in serious neonatal infections. J. Infect. Dis. 124 Suppl. (1971) 224–231.

    Google Scholar 

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Kaul, S., D'Cruz, J., Glista, B. et al. Ventriculitis, aqueductal stenosis and hydrocephalus in neonatal meningitis: Diagnose and treatment. Infection 6, 8–11 (1978).

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  • Public Health
  • Internal Medicine
  • Infectious Disease
  • General Practice
  • Meningitis