Summary
Various groups were examined for all types of antigens and antibodies associated withHepatitis B virus (HBV). All combinations of humoral immunological response occurred in the HBsAg-positive and HBsAg-negative groups. Reduced IgA and IgM titers were found in HBsAg carriers. There is a possible correlation between these lowered titers and the immuno-suppressive factors discussed here with respect to HBsAg.
Zusammenfassung
Verschiedene Gruppen wurden auf sämtliche mitHepatitis B-Virus (HBV) assoziierten Antigene und Antikörper untersucht. In den HBsAg-positiven und HBsAg-negativen Gruppen kamen alle Kombinationen der humoralen Immunantwort vor. Bei HBsAg-Trägern fanden sich erniedrigte IgA und IgM Titer. Möglicherweise besteht eine Korrelation zwischen diesen erniedrigten Titern und immunsuppressiven Faktoren, die im Zusammenhang mit HBsAg zur Diskussion stehen.
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Literature
Axelsen, N. H., Kroll, J., Weeke, B. A manual of quantitative immunoelectrophoresis methods and applications. Universitetforlaget, Oslo 1973, pp. 38–48.
Zuckerman, A. J. Human viral hepatitis — hepatitis-associated antigen and viruses. Elsevier/North-Holland Biomedical Press, Amsterdam, New York, Oxford 1975, pp. 100–102.
Hess, G., Arnold, W., Gahl, G. M., Vogl, E., Meyer zum Büschenfelde, K. H. Significance of antibody to Hepatitis B e antigen (Anti-HBe) in HBsAg-negative individuals. Vox. Sang. 40 (1981) 95–98.
Hoofnagle, J. H., Seef, L. B., Bales, Z. B., Zimmerman, H. J. Type B hepatitis after transfusion with blood containing antibody to hepatitis B core antigen. N. Engl. J. Med. 298 (1978) 1379–1383.
Katchaki, J. N., van der Waart, M., Sien, T. H., Brouwer, R., Schuurs, A. H. W. M. The occurrence of antibody markers ofHepatitis B virus infection in an HBsAg-negative blood donor population. Vox. Sang. 37 (1979) 9–13.
Nagington, J., Cossart, Y. E., Cohen, B. J. Reactivation of hepatitis B after transplantation operations. Lancet I (1977) 558–560.
Hess, G., Arnold, W. The clinical relevance of the antibody to Hepatitis B core antigen (anti-HBc): a review. J. Virol. Meth. 2 (1980) 107–117.
Gerlich, W., Luer, W. Diagnosis of acute and inapparentHepatitis B virus infections by measurement of IgM antibody to hepatitis B core antigen. J. Infect. Dis. 142 (1980) 95–101.
Nielsen, J. O. Acute viral hepatitis: A comparative study of clinical, biochemical, morphological features in patients with and without Australia antigen. Scand. J. Infect. Dis. 7 (1975) 173–177.
Vyas, G. N. Hepatitis in selective IgA deficiency? Br. Med. J. 1 (1975) 736.
Sutnick, A. J., Bugbec, S. J., London, W. T., Pegretti, F., Litnin, S., Blumenberg, B. S. Susceptibility to persistence of Australia antigen. Arch. Intern. Med. 135 (1975) 1072–1074.
Berg, P. A., Brattig, N., Grauer, W. Immunosuppressive serum factors in viral hepatitis. International Congress of Liver Diseases. Virus and the liver. Falk Symposium 28 (1980) 175–181.
Vranckx, R.: Epidemiologische en immuno-chemische aspekten van hetHepatitis B virus en evaluatie van de immuniteit bij symptoomloze HBsAg dragers. Academic dissertation. University of Antwerp, 1980.
Kaklamani, E., Kyriakidou, A., Trichopoulos, D., Papoutsakis, G. Koumandaki, I., Karalis, D. Hepatitis B serology in Greek prostitutes: Significance of the different serum markers. J. Hyg. Camb. 84 (1980) 257–261.
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Vranckx, R. Humoral immune response in Hepatitis B virus infections. Infection 11, 114–117 (1983). https://doi.org/10.1007/BF01641076
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DOI: https://doi.org/10.1007/BF01641076