Summary
Anin vitro bacteriological study of 449 recent clinical isolates from 23 species was conducted to investigate the activity of cefoperazone, a new cephalosporin antibiotic. The sensitivity distribution for each species confirmed that cefoperazone possesses a wide spectrum of activity. It also showed that bacteria may be divided into four groups according to the minimum inhibitory concentrations (MICs) of cefoperazone: 0.5 mg/l or less; >0.5 to ≤4 mg/l; >4 to ≤32 mg/l; and more than 32 mg/l. A few strains had MICs that were higher than 64 mg/l. Dosage and frequency of administration are discussed in relation to bacterial sensitivity, taking into account the pharmacokinetics of cefoperazone given by the intramuscular and intravenous routes in doses of 0.5 g, 1 g and 2 g.
Zusammenfassung
449 frische klinische Isolate von 23 Spezies wurden in einer bakteriologischenin vitro Studie zur Testung der Aktivität von Cefoperazon, einem neuen Cephalosporin Antibiotikum, untersucht. Aus dem Resistenzverhalten der einzelnen Spezies war ein breites Wirkungsspektrum von Cefoperazon abzuleiten. Bezogen auf die minimalen Hemmkonzentrationen (MHK) von Cefoperazon ergab sich eine Einteilung der Bakterien in vier Gruppen: 0,5 mg/l oder darunter; >0,5 bis ≤4 mg/l; >4 bis ≤32 mg/l und mehr als 32 mg/l. Einige wenige Stämme wiesen MHK von über 64 mg/l auf. Dosierung und Häufigkeit der Anwendung werden unter Berücksichtigung des bakteriellen Resistenzverhaltens und der Pharmakokinetik von Cefoperazon nach intramuskulärer und intravenöser Verabreichung in Dosen von 0,5 g, 1 g und 2 g diskutiert.
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Acar, J.F., Kitzis, M.D. Clinical implications of the microbiological and pharmacokinetic properties of cefoperazone. Infection 9 (Suppl 1), S17–S23 (1981). https://doi.org/10.1007/BF01641033
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DOI: https://doi.org/10.1007/BF01641033