Summary
Sixty-seven household contacts of 31 index cases with acute HBsAg-positive hepatitis were investigated forHepatitis B virus (HBV) markers. Follow-up findings in 50 household contacts revealed that six spouses and/or sexual partners had developed acute clinical hepatitis B. Three of these six contacts were drug addicts. A further seven contacts showed serological changes compatible with exposure to HBV, but had no signs of acute clinical hepatitis. Six of these seven contacts were spouses and/or sexual partners of their index case. Possible prophylactic or post-exposure measures only seem to be necessary in the spouses and/or sexual partners of patients with acute hepatitis B.
Zusammenfassung
Siebenundsechzig Personen, die in häuslichem Milieu Kontakt zu 31 Fällen mit akuter HBsAg-positiver Hepatitis hatten, wurden auf Hepatitis-B-Virus (HBV) Marker untersucht. In Verlaufskontrollen bei 50 Personen mit Kontakt zu den Hepatitis-Kranken zeigte sich, daß sechs Ehegatten und/oder Geschlechtspartner eine klinisch akute Hepatitis B entwickelt hatten. Weitere sieben Kontaktpersonen wiesen serologische Veränderungen auf, die mit einer Exposition gegenüber HBV vereinbar waren; doch hatten diese Personen keine klinisch manifeste Hepatitis. Sechs dieser sieben Kontaktpersonen waren Ehegatten und/oder Geschlechtspartner des jeweiligen Hepatitisfalles. Prophylaktische oder therapeutische Maßnahmen nach Exposition scheinen nur bei Ehegatten und/oder Geschlechtspartnern von Patienten mit akuter B-Hepatitis erforderlich zu sein.
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Other members of the group:P. Christoffersen, O. Dietrichson, V. Faber, C. Gluud, G. Høybye, K. Iversen, E. Juhl, P. Kryger, L. R. Mathiesen, P. Petersen, H. Poulsen, P. Schlichting, P. Skinhøj, T. I. A. Sørensen.
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the Copenhagen Hepatitis Acuta Programme., Aldershvile, J., Hardt, F. et al. Hepatitis B virus infection among household contacts of patients with acute HBsAg-positive hepatitis. Infection 9, 164–166 (1981). https://doi.org/10.1007/BF01640971
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DOI: https://doi.org/10.1007/BF01640971