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Recent progress in the understanding of the role of bacterial adhesion in the pathogenesis of urinary tract infection

Die Rolle der Bakterien-Adhäsion in der Pathogenese der Harnwegsinfektion. Neue Forschungsergebnisse

  • The Fifth Sils Maria Symposium
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Summary

There is extensive evidence indicating that the capacity ofEscherichia coli to attach to the mucosal lining of the urinary tract is a virulence factor in acute pyelonephritis in the unobstructed state.In vitro results using human uroepithelial cells and clinicalE. coli isolates as well asin vivo work on ascending urinary tract infection in mice andE. coli strains with genetically defined adhesins support this notion. The biochemical characterization of the bacterial ligands and epithelial cell receptors important for the attachment of most pyelonephritogenicE. coli provides a more sophisticated means of evaluating the role of bacterial adhesion in urinary tract infection: 1) It allows precise diagnosis of the receptor specificity of clinical isolates; 2) The receptor can be used to isolate the relevant bacterial adhesins; 3) The localization and quantity of the receptor in the patient may be of prognostic importance; 4) The administration of soluble receptor analogues or antibodies to the adhesins may be useful for prophylactic and/or therapeutic purposes.

Zusammenfassung

Es gibt zahlreiche Hinweise dafür, daß die Adhäsionsfähigkeit vonEscherichia coli an der Schleimhaut der Harnwege ein Virulenzfaktor für die Entstehung der nicht obstruktiven, akuten Pyelonephritis ist. Diese Vorstellung stützt sich auf Ergebnisse vonIn-vitro-Studien an menschlichen uroepithelialen Zellen mit klinischen Isolaten vonE. coli sowie vonin vivo-Studien am Modell der aufsteigenden Harnwegsinfektion der Maus unter Verwendung vonE.-coli-Stämmen mit genetisch definierten Adhäsinen. Die biochemische Charakterisierung der Bakterien-Liganden und der für die Adhäsion der meisten pyelonephritogenenE. coli-Stämme wichtigen Epithelzell-Rezeptoren ermöglicht eine methodisch differenziertere Abklärung der Rolle der Bakterienadhäsion für die Harnwegsinfektion: 1) Sie ermöglicht eine exakte Diagnose der Rezeptorspezifität klinischer Isolate; 2) Der Rezeptor kann zur Isolierung der relevanten Bakterien-Adhäsine eingesetzt werden; 3) Die Lokalisation des Rezeptors und seine Quantität kann für den Patienten prognostisch bedeutsam sein; 4) Die Anwendung löslicher Rezeptoranaloga oder von Antikörpern gegen Adhäsine ist möglicherweise von prophylaktischem und/oder therapeutischem Nutzen.

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Literature

  1. Svanborg Edén, C., Leffler, H. Glycosphingolipids of human urinary tract epithelial cells as possible receptors for adheringE. coli bacteria. Symposium on Host-parasite Interaction, Umeå, Sweden, June 1979. Scand. J. Infect. Dis. Suppl. 24 (1980) 144–147.

    Google Scholar 

  2. Leffler, H., Svanborg Edén, C. Chemical identification of glycolipid receptors for uropathogenicE. coli attaching to human urinary tract epithelial cells and agglutinating human erythrocytes. FEMS Microbiol. Lett. 8 (1980) 127–134.

    Article  CAS  Google Scholar 

  3. Källenius, G., Möllby, R., Svensson, S. B., Winberg, J., Lundblad, A., Svensson, S., Cedergren, B. The Pk antigen as receptor for the hemagglutinin of pyelonephriticE. coli. FEMS Microbiol. Lett. 7 (1980) 297–302.

    Article  Google Scholar 

  4. Leffler, H., Svanborg Edén, C. Glycolipid receptors for uropathogenicE. coli binding to human erythrocytes and uroepithelial cells. Infect. Immun. 34 (1981) 920–929.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Väisänen, V., Elo, J., Tallgren, L., Siitonen, A., Mäkelä, P. H., Svanborg Edén, C., Källenius, G., Svensson, S. B., Hultberg, H., Korhonen, T. K. Mannose-resistant hemagglutination and P antigen recognition characteristic ofE. coli causing primary pyelonephritis. Lancet II (1981) 1366–1369.

    Article  Google Scholar 

  6. Källenius, G., Möllby, R., Svensson, S. B., Helin, I., Hultberg, H., Cedergren, B., Winberg, J. Incidence of P-fimbriatedE. coli in urinary tract infections. Lancet II (1981) 1369–1372.

    Article  Google Scholar 

  7. Svanborg Edén, C., Hagberg, L., Hanson, L. Å., Korhonen, T. K., Leffler, H., Olling, S.: Adhesion ofE. coli in urinary tract infection. In: Adhesion and microorganism pathogenicity. Ciba Symposium 80, Pitman Medical, Tunbridge Wells 1981, pp. 161–187.

  8. Svanborg Edén, C., Fasth, A., Hagberg, L., Hanson, L. Å., Korhonen, T. K., Leffler, H. Host interaction withEscherichia coli in the urinary tract. In:Robbins, J. B., Hill, J. C., Sadoff, J. C. (eds.): Bacterial vaccines. Thieme Stratton, New York 1982, pp. 113–131.

    Google Scholar 

  9. Ørskov, I., Ørskov, F., Birch-Andersen, A. A fimbriaE. coli antigen, F7, determining uroepithelial adherence. Comparison with type 1 fimbriae which attach to urinary slime. Infect. Immun. 27 (1980) 657–666.

    PubMed  PubMed Central  Google Scholar 

  10. Svenson, S. B., Hultberg, H., Källenius, G., Korhonen, T. K., Möllby, R., Winberg, J.: P-fimbriae of pyelonephritogenicEscherichia coli: Identification and chemical characterization of receptors. Infection 10 (1982) (in print).

  11. Hagberg, L., Jodal, U., Korhonen, T. K., Lidin-Janson, G., Lindberg, U., Svanborg Edén, C. Adhesion, hemagglutination and virulence ofE. coli causing urinary tract infections. Infect. Immun. 31 (1981) 564–570.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Svanborg Edén, C., Gotschlich, E. C., Korhonen, T. K., Leffler, H., Schoolnik, G.: Aspects on structure and function of pili on uropathogenicE. coli. Progress in Allergy (1982) (in print).

  13. Leffler, H., Lomberg, H., Gotschlich, E. C., Hagberg, L., Jodal, U., Korhonen, T., Samuelsson, B. E., Schoolnik, G., Svanborg Edén, C. Chemical and clinical studies on the interaction ofE. coli with host glycolipid receptors in urinary tract infection. Scand. J. Infect. Dis. Suppl. 33 (1982) 26–32.

    Google Scholar 

  14. Svanborg Edén, C., Freter, R., Hagberg, L., Hull R., Hull, S., Leffler, H., Lomberg, H., Schoolnik, G.: Adherence to uroitheliain vivo andin vitro. Microbiology (1982) in print.

  15. Leffler, H., Svanborg Edén, C., Schoolnik, G., Wadström, T. Glycosphingolipids as receptors for bacterial adhesion. Host glycolipid diversity and other selected aspects. In:Boedekker, E. C. (ed.): Attachment of microorganisms to the gastrointestinal mucosal surface. CRC press, Boca Raton 1982 (in print).

    Google Scholar 

  16. Watkins, W. M. Genetics and biochemistry of some human blood groups. Proc. R. Soc. B 202 (1978) 31–53.

    Article  CAS  Google Scholar 

  17. Fletcher, K. S., Bremer, E. G., Schwarting, G. A. P blood group regulation of glycosphingolipid levels in human erythrocytes. J. Biol. Chem. 254 (1979) 11196–11198.

    CAS  PubMed  Google Scholar 

  18. Lomberg, H., Jodal, U., Svanborg Edén, C., Leffler, H., Samuelsson, B. P1 blood group and urinary tract infection. Lancet I (1981) 551–552.

    Article  Google Scholar 

  19. Fowler, J. E., Stamey, T. A. Studies of introital colonization in women with recurrent urinary tract infections. J. Urol. 117 (1977) 472–476.

    PubMed  Google Scholar 

  20. Källenius, G., Winberg, J. Bacterial adherence to periurethral cells in girls prone to urinary tract infections. Lancet II (1978) 540–543.

    Article  Google Scholar 

  21. Svanborg Edén, C., Hull, R., Hull, S., Leffler, H.: Target cell specificity of wild-typeE. coli and strains with genetically defined adhesins. Nutrition Research (1982) (in print).

  22. Svanborg Edén, C., Freter, R., Hagberg, L., Hull, R., Hull, S., Leffler, H., Schoolnik, G. Inhibition of experimental ascending urinary tract infection by receptor analogue. Nature 298 (1982) 560–562.

    Article  Google Scholar 

  23. Beachey, E. H. Bacterial adherence: Adhesin-receptor interactions mediating the attachment of bacteria to mucosal surfaces. J. Infect. Dis. 143 (1981) 325–345.

    Article  CAS  PubMed  Google Scholar 

  24. Evans, D. G., Evans, D. J., Tjoa, W. Hemagglutination of human group A erythrocytes by enterotoxigenicE. coli isolated from adults with diarrhea: correlation with colonization factor. Infect. Immun. 18 (1977) 330–337.

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Immunology and Pediatrics, University of Göteborg, S-413 46, Göteborg, Sweden

    Catharina Svanborg Edén M. D., Ph. D., L. Hagberg M. D. & H. Lomberg

  2. Department of Medical Biochemistry, University of Göteborg, S-413 46, Göteborg, Sweden

    H. Leffler M. D., Ph. D.

Authors
  1. Catharina Svanborg Edén M. D., Ph. D.
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  2. L. Hagberg M. D.
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  3. H. Lomberg
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  4. H. Leffler M. D., Ph. D.
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Edén, C.S., Hagberg, L., Lomberg, H. et al. Recent progress in the understanding of the role of bacterial adhesion in the pathogenesis of urinary tract infection. Infection 10, 327–332 (1982). https://doi.org/10.1007/BF01640890

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