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The effect of n-formimidoyl thienamycin, ceftazidime, cefotiam, ceftriaxone and cefotaxime on non-fermentative gram-negative rods, Aeromonas, Plesiomonas and Enterobacter agglomerans

Die Wirkung von N-Formimidoyl-Thienamycin, Ceftazidim, Cefotiam, Ceftriaxon und Cefotaxim gegenüber nichtfermentierenden gramnegativen Stäbchen, Aeromonas, Plesiomonas und Enterobacter agglomerans

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Summary

Thirty-one species (185 strains) of non-fermentative gram-negative rods (excludingPseudomonas aeruginosa) as well as 45 strains ofAeromonas spp., 15 strains ofPlesiomonas shigelloides and 68 strains ofEnterobacter agglomerans were tested in microdilution procedures against N-formimidoyl thienamycin, ceftazidime, cefotiam, ceftriaxone and cefotaxime. N-formimidoyl thienamycin was the most effective drug as far as the spectrum of these bacterial groups and potency is concerned; ceftazidime was the second most effective agent. Ceftriaxone and cefotaxime were similar in their activity (against a smaller spectrum), while cefotiam showed little effect. There were occasional differences between MBC and MIC values which were most notable with ceftazidime, cefotiam, ceftriaxone and cefotaxime againstE. agglomerans.

Zusammenfassung

31 Spezies (185 Stämme) nichtfermentierender gramnegativer Stäbchen (außerPseudomonas aeruginosa) sowie 45Aeromonas spp.-, 15Plesiomonas shigelloides- und 68Enterobacter agglomerans-Stämme wurden im Mikrodilutionstest gegen N-Formimidoyl-Thienamycin, Ceftazidim, Cefotiam, Ceftriaxon und Cefotaxim getestet. N-Formimidoyl-Thienamycin erwies sich als das wirksamste Mittel, sowohl bezüglich seines Spektrums der genannten Bakteriengruppen als auch bezüglich seiner Dosis-Wirkung. Ceftazidim war das zweitwirksamste Mittel. Ceftriaxon und Cefotaxim zeigten gleiche Wirksamkeit gegenüber einem schmäleren Erregerspektrum. Cefotiam zeigte nur geringe Aktivität. Gelegentliche Differenzen zwischen MBK- und MHK-Werten wurden beobachtet, am hervorstechendsten bei Ceftazidim, Cefotiam, Ceftriaxon und Cefotaxim gegenüberE. agglomerans.

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  1. Institut für Medizinische Mikrobiologie der Universität Zürich, Gloriastrasse 30, CH-8028, Zürich, Switzerland

    A. von Graevenitz & C. Bucher

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  1. A. von Graevenitz
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von Graevenitz, A., Bucher, C. The effect of n-formimidoyl thienamycin, ceftazidime, cefotiam, ceftriaxone and cefotaxime on non-fermentative gram-negative rods, Aeromonas, Plesiomonas and Enterobacter agglomerans. Infection 10, 293–298 (1982). https://doi.org/10.1007/BF01640878

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