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Correlation of minimum inhibitory concentration and beta-lactamase activity

Beziehung zwischen minimaler Hemmkonzentration und Beta-Lactamase-Aktivität

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Summary

The beta-lactamase activity of 510 recently isolated Enterobacteriaceae was investigated with a quantitative photometric test. Beta-lactamase could be detected in 55 percent of the Enterobacteriaceae. At the same time minimal inhibition concentration (MIC) of beta-lactam antibiotics was determined. There was no correlation between MIC values and lactamase activity. For correct antibacterial therapy the clinician requires information on the lactamase activity of isolated bacteria in addition to the antibiogram. The qualitative test is useful for screening.

Zusammenfassung

Die Beta-Lactamase-Aktivität von 510 frisch isolierten Enterobacteriaceen wurde mit einem quantitativen photometrischen Test untersucht. Bei 55 Prozent aller Enterobacteriaceen war Beta-Lactamase nachzuweisen. Die gleichzeitig vorgenommene Bestimmung der minimalen Hemmkonzentration (MHK) gegenüber β-Lactamantibiotika ergab keine Korrelation zwischen MHK-Wert und beta-Lactamase-Aktivität. Für eine rationelle Antibiotikum-Therapie scheint es daher geboten, dem behandelnden Arzt nben dem Antibiogramm die β-Lactamase-Aktivität des isolierten Bakterienstammes mitzuteilen. Hierzu durchaus geeignet ist der qualitative Enzymnachweis.

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Literature

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Authors and Affiliations

  1. Hygiene-Institut, University of Tübingen, Silcherstraße 7, D-7400, Tübingen

    U. Ullmann

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  1. U. Ullmann
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Ullmann, U. Correlation of minimum inhibitory concentration and beta-lactamase activity. Infection 5, 261–262 (1977). https://doi.org/10.1007/BF01640794

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  • DOI: https://doi.org/10.1007/BF01640794

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