Summary
During the October 1973 military conflict, 41 burned patients hospitalized at the Sheba Medical Center were closely followed up. All the patients who had burns occupying 20% or more of the body surface developed wound infections. Pseudomonas aeruginosa was the major pathogen isolated. Most infections occurred during the second week following the injury. Serial cultures revealed that only the isolation of Proteus species and P. aeruginosa from wounds could predict an infection caused by those microorganisms. During treatment with gentamicin and carbenicillin a marked increase in carbenicillin-resistant P. acruginosa and gentamicin-resistant Klebsiella strains was noted. Cross-infection with carbenicillin-resistant P. aeruginosa was not a major cause in the development of resistant strains.
Zusammenfassung
Während des Yom-Kippur-Krieges wurden die Krankheitsverläufe von 41 Patienten mit Verbrennungen im Sheba Medical Center genau erfaßt. Alle Patienten, die Verbrennungen von 20% oder mehr der Hautoberfläche aufwiesen, entwickelten Wundinfektionen. Der am häufigsten isolierte Erreger war Pseudomonas acruginosa. Die meisten Infektionen traten während der zweiten Woche nach der Verbrennung auf. Verlaufskulturen bewiesen an Hand der alleinigen Isolierung von Proteus-Spezies und P. aeruginosa, daß eine Infektion durch diese Keime zustande kam. Während der Behandlung mit Gentamicin und Carbencillin trat ein deutlicher Anstieg von Carbencillin-resistenten P. aeruginosa und Gentamicin-resistenten Klebsiella-Stämmen auf. Die Übertragung von Carbencillin-resistenten P. aeruginosa im Hospital war nicht in erster Linie für das Auftreten der resistenten Stämme verantwortlich.
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Literature
Alexander, J. W. Control of infection following burn injury. Arch. Surg. 103 (1971) 435–441.
Baxter, C. R., Curreri, R. W., Marvin, J. A. Control of burn wound sepsis. Surg. Clin. N. Amer. 53 (1973) 1509–1518.
Bruck, H. M., Nash, G., Stein, J. M., Lindberg, R. B. Studies on the occurrence and significance of yeasts and fungi in the burn wound. Ann. Surg. 176 (1972) 108–110.
Cox, C. E. Gentamicin. Med. Clin. N. Amer. 54 (1970) 1305–1315.
Duncan, I. B. R. Susceptibility of 1500 isolates of Pseudomonas aeruginosa to gentamicin, carbenicillin, colistin and polymixin B. Antimicrob. Ag. Chemoth. 5 (1974) 9–15.
Foley, F. D., Moncrief, J. A., Mason, A. D. Pathology of the lung in the fatally burned patients. Ann. Surg. 167 (1968) 251–264.
Foley, F. D. The burn autopsy: Fatal Complications of burns. Amer. J. Clin. Pathol. 52 (1969) 1–13.
Fullbrock, P. D., Elson, S. W., Slocombe, B. R-factor mediatedβ-lactamase in Pseudomonas aeruginosa. Nature 226 (1970) 1054–1056.
Greene, W. H., Moody, M., Schimpff, S., Young, V. M., Wiernik, P. H. Pseudomonas aeruginosa resistant to carbenicillin and gentamicin. Ann. Int. Med. 79 (1973) 684–689.
Hoffman, T. A., Bullock, W. E. Carbenicillin therapy of Pseudomonas and other gram negative bacillary infections. Ann. Int. Med. 73 (1970) 165–171.
Holmes, R. K., Minshew, B. H., Gould, K., Sanford, J. P. Resistance of Pseudomonas aeruginosa to gentamicin and related aminoglycoside antibiotics. Antimicrob. Ag. Chemother. 6 (1974) 253–257.
Jones, R. J., Jackson, D. M. G., Lowbury, E. J. L. Antiserum and antibiotics in the prophylaxis of burns against Pseudomonas aeruginosa. Brit. J. Plast. Surg. 19 (1968) 43–57.
Jones, R. J., Lowbury, E. J. L. Prophylaxis and therapy for Pseudomonas aeruginosa infection with carbenicillin and with gentamicin. Brit. med. J. 3 (1967) 79–82.
Kefalides, N. A., Arana, J. A., Bazan, A., Velarde, N., Rosenthal, S. M. Evaluation of antibiotic prophylaxis and gamma globulin, plasma albumin and saline solution therapy in severe burns. Ann. Surg. 159 (1964) 496–506.
Lowbury, E. J. L., Lilly, H. A., Kidson, A., Ayliffe, G. A. J. Sensitivity of Pseudomonas aeruginosa to antibiotics: Emergence of strains highly resistant to carbenicillin. Lancet (1969/II) 448–452.
Lowbury, E. J. L. Infection associated with burns. Postgrad. Med. J. 48 (1972) 338–343.
Lowbury, E. J. L., Rabb, J. R., Roe, E. Clearance from a hospital of gram negative bacilli that transfer carbenicillin resistance to Pseudomonas aeruginosa. Lancet (1972/II) 941–945.
Marks, M. I., Eickhoff, T. C. Carbenicillin: A clinical and laboratory evaluation. Ann. Int. Med. 73 (1970) 179–187.
Moncrief, J. A. Burns. N. Eng. J. Med. 288 (1973) 444–454.
Pruitt, B. A., Divincenti, F. C., Mason, A. D., Foley, F. D., Flemma, R. J. The occurrence and significance of pneumonia and other pulmonary complications in burned patients: Comparison of conventional and typical treatment. J. Trauma 10 (1970) 519–531.
Pruitt, B. A. Infections caused by Pseudomonas species in patients with burns and in other surgical patients. J. Inf. Dis. 130 (1974) Suppl. 58–66.
Roe, E., Jones, R. J., Lowbury, E. J. L. Transfer of antibiotic resistance between Pseudomonas aeruginosa, E. coli and gram negative bacilli in burns. Lancet (1972/I) 149.
Shuck, J. M. Infection control in burns: Topical and systemic. Surg. Clin. N. Amer. 52 (1972) 1425–1438.
Simchen, E., Sachs, T. Infection in war wounds. Experience during the 1973 October war in Israel. Ann. Surg. 182 (1975) 754–761.
Stone, H. H., Kolb, L. D. The evaluation and spread of gentamicin resistant Pseudomonas. J. Trauma 11 (1971) 586–589.
Wickman, K. Studies on burns' bacteriology. Acta Chir. Scand. Suppl. 408 (1970) 1–34.
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Sidi, Y., Bogokowski, B., Tsur, H. et al. Infectious complications of burns casualties during the yom-kippur war. Infection 5, 214–218 (1977). https://doi.org/10.1007/BF01640783
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DOI: https://doi.org/10.1007/BF01640783