Summary
A small epidemic of listeric infection among non-compromised adults recently occurred in the western part of Sweden. All ten patients survived and the prognosis of listeric meningitis in non-compromised patients would seem to be considerably better than in the compromised host. A rapid initiation of ampicillin treatment (10–20 mg/kg of body weight daily) within 48 hours after onset of symptoms may have contributed to the excellent outcome in the present series besides a well-functioning intracellular killing mechanism which seems to be of the greatest importance in listeric infection.
Zusammenfassung
Eine Listerien-Epidemie bei immunologisch intakten Erwachsenen trat vor einiger Zeit im westlichen Teil Schwedens auf. Alle zehn Patienten überlebten. Die Prognose der Listerien-Meningitis bei immunologisch nicht beeinträchtigten Patienten scheint beträchtlich besser zu sein als bei vorgeschädigten. Eine rasche Anwendung von Ampicillin (10–20 mg/kg/KG täglich) innerhalb der ersten 48 Stunden nach Einsetzen der klinischen Symptome mögen zu dem ausgezeichneten Ergebnis bei den beobachteten Fällen beigetragen haben, möglicherweise deswegen, weil ein gut funktionierender intrazellulärer Abtötungsmechanismus dieser Bakterien bei Listerien-Infektionen von größter Bedeutung sein kann.
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Literature
Gray, M. L., Killinger, A. H. L. monocytogenes and listeric infections. Bact. Rev. 30 (1966) 309–382.
Louria, D., Hensle, T., Armstrong, D., Collins, H. S., Blevins, A., Krugmann, D., Buse, M. Listeriosis complicating malignant disease. A new association. Ann. Intern. Med. 67 (1967) 261–281.
Simpson, J. F., Leddy, J. P., Hau, J. D. Listeriosis complicating lymphoma. Report of four cases and interpretive review of pathogenetic factors Amer. J. Med. 43 (1967) 39–49.
Mahony, J. F., Tambyah, J. A., Dalton, V. C., Wolfenden, W. H. Pontomedullary listeriosis in renal allograft recipient. Brit. med. J. 2 (1974) 705.
Mackaness, G. B. The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J. exp. Med. 128 (1969) 973–992.
Zinkernagel, R. M., Doherty, P. C. Cortisone-resistant effector T-cells in acute lymphocytic choriomeningitis and Listeria monocytogenes infection of mice. Austra. J. Exp. Biol. Med. Sci. 53 (1975) 297–303.
Simon, H. B., Sheagren, J. N. Cellular immunity in vitro. I. Immunologically mediated enhancement of macrophage bactericidal capacity. J. exp. Med. 133 (1971) 1377–1389.
Adam, D., Staber, F., Belohradsky, B., Marget, W. Effect of dihydrostreptomycin on phagocytosis of mouseperitoneal macrophages in vitro. Infect. Immun. 5 (1972) 537–541.
Cole, P., Brostoff, J. Intracellular killing of Listeria monocytogenes by activated macrophages (Mackaness system) is due to antibiotic. Nature 356 (1975) 515–517.
Magoffin, R. L., Spink, W. W. The protection of intracellular Brucella against streptomycin alone and in combination with other antibiotics. J. Lab. clin. Med. 37 (1951) 924–930.
Shaffer, J. M., Kucera, C. J., Spink, W. W. The protection of intracellular Brucella against therapeutic agents and the bactericidal action of serum. J. exp. Med. 97 (1953) 77–89.
Weingärtner, L., Ortel, S. Zur Behandlung der Listeriose mit Ampicillin. Dtsch. med. Wschr. 92 (1967) 1098–1102.
Ortel, S. Bakteriologische, serologische und epidemiologische Untersuchungen während einer Listeriose-epidemi. Dtsch. Gesundh.-Wes. 23 (1968) 753–759.
Boijsen-Möller, J. Occurrence of Listeria monocytogenes in faeces from healthy and sick persons. Proc. 14th. Scand. Congr. Pathol. Microbiol., Oslo 1964, p. 97. Norwegian Universities Press, Oslo 1964.
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Iwarson, S., Lidin-Janson, G. & Svensson, R. Listeric meningitis in the non-compromised host. Infection 5, 204–206 (1977). https://doi.org/10.1007/BF01640780
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DOI: https://doi.org/10.1007/BF01640780