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Comparative activity of six beta-lactam antibiotics against strains of haemophilus influenzae, neisseria meningitidis and streptococcus pneumoniae

Vergleich der Aktivität von sechs Beta-Lactam-Antibiotika gegenüber Stämmen von Haemophilus influenzae, Neisseria meningitidis und Streptococcus pneumoniae

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Summary

The minimum inhibitory concentrations (MIC) of penicillin G, ampicillin, mezlocillin, azlocillin, cephalothin and cefoxitin were determined for 47 strains ofHaemophilus influenzae, 68 strains ofNeisseria meningitidis and 45 strains ofStreptococcus pneumoniae. These strains were isolated during the past three years from patients with acute bacterial meningitis. Three strains ofH. influenzae were ampicillin-resistant while no pneumococcus or meningococcus strain was penicillin-resistant. Mezlocillin was the most potent antibiotic against theHaemophilus and pneumococcus strains, followed closely by azlocillin. Mezlocillin inhibited 77.7% of the meningococci strains tested at a concentration of 0.03 mg/l. Penicillin G was the most effective of the drugs against these strains. It inhibited 100% at a concentration of 0.5 mg/l. The cephalosporins were the least active of the six betalactam antibiotics tested.

Zusammenfassung

Die minimale Hemmkonzentration (MHK) von Penicillin G, Ampicillin, Mezlocillin, Azlocillin, Cephalotin und Cefoxitin für 47 Stämme vonHaemophilus influenzae, 68 Stämme vonNeisseria meningitidis und 45 Stämme vonStreptococcus pneumoniae wurde bestimmt. Diese Stämme waren von Patienten mit akuter bakterieller Meningitis während der letzten drei Jahre isoliert worden. Drei Stämme vonH. influenzae waren resistent gegen Ampicillin. Keiner der Pneumokokken oder Meningokokken war Penicillin-resistent. Mezlocillin war gegenHaemophilus und Pneumokokken am wirksamsten, gefolgt von Azlocillin. Mezlocillin hemmte 77,7% der getesteten Meningokokken bei 0,03 mg/l und Penicillin G mit einer Hemmung von 100% der Stämme bei 0,5 mg/l war das wirksamste Meningokokken-Antibiotikum. Die Cephalosporine wirkten von den sechs Beta-Lactam-Antibiotika am schwächsten auf die getesteten Stämme.

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Authors and Affiliations

  1. Research Laboratory of Microbiology, Bayer do Brasil S. A., Caixa Postal 959, 01000, Sao Paulo, Brasil

    L. A. Soares

  2. Department of Bacteriology, Instituto Adolfo Lutz, Sao Paulo, Brasil

    C. E. A. Melles

Authors
  1. L. A. Soares
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  2. C. E. A. Melles
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Soares, L.A., Melles, C.E.A. Comparative activity of six beta-lactam antibiotics against strains of haemophilus influenzae, neisseria meningitidis and streptococcus pneumoniae. Infection 10 (Suppl 3), S234–S237 (1982). https://doi.org/10.1007/BF01640680

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