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Mechanisms of pathogenicity of anaerobic bacteria of clinical interest

Pathogenitätsmechanismen von klinisch bedeutsamen anaeroben Bakterien

  • Etiology And Pathogenesis Of Anaerobic Infections
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Summary

The host factors leading to anaerobic infection and the various models of anaerobic infection, namely direct effect of a single toxin, multiple toxinaggressin-systems, enterotoxic mechanisms, endogenous infections with non-clostridial anaerobes, and synergistic infections, are reviewed. Production of carcinogens and co-carcinogens by anaerobes is also discussed.

Zusammenfassung

Die zur Anaerobierinfektion führenden Wirtsfaktoren und die verschiedenen Modelle der Anaerobierinfektion, nämlich direkter Effekt eines einzelnen Toxins, multiple Toxin-Aggressin-Systeme, enterotoxische Mechanismen, endogene Infektionen mit nicht-clostridialen Anaerobiern sowie synergistische Infektionen, werden dargelegt. Die Bildung von Carcinogenen und Co-Carcinogenen durch Anaerobier wird ebenfalls diskutiert.

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Literature

  1. Stanier, R. Y., Doudoroff, M., Adelberg, E. A. General microbiology. Macmillan, London 1958, p. 463.

    Google Scholar 

  2. Bullen, J. J. Role of toxins in host-parasite relationships: In:Ajl, S. J., Kadis, S., Montie, T. C. (ed): Microbial toxins, vol. 1. Academic Press, New York/London 1970, p. 233–276.

    Google Scholar 

  3. Leading article Hyperbaric oxygen. Br. Med. J. I (1978) 1012.

    Google Scholar 

  4. Parker, M. T. Post operative clostridial infections in Britain. Br. Med. J. III (1969) 671–676.

    Google Scholar 

  5. Collee, J. G. Clostridium perfringens (Cl. welchii) in the human gastro-intestinal tract: In:Skinner, F. A., Carr, J. G. (ed.): The normal microbial flora of man. Academic Press, London 1974, p. 205–219.

    Google Scholar 

  6. Hobbs, B. C., Smith, M. E., Oakley, C. L., Warrack, G. H., Cruickshank, J. C. Clostridium welchii food poisoning. J. Hyg. (Camb.) 51 (1953) 75–101.

    Google Scholar 

  7. Hauschild, A. H. W.: Enterotoxin ofClostridium perfringens: In:Balows, A., De Haan, R. M., Dowell, V. R. jr., Guze, L. B. (ed.): Anaerobic bacteria: Role in disease, Thomas, Springfield, p. 149–155.

  8. Zeissler, J., Rassfeld-Sternberg, L. Enteritis necroticans due toClostridium welchii type F. Br. Med. J. I (1949) 267–269.

    Google Scholar 

  9. Murrell, T. G. C., Roth, L., Egerton, J., Samels, J., Walker, P. D. Pig-bel: Enteritis necroticans. A study in diagnosis and management. Lancet I (1966) 217–222.

    Google Scholar 

  10. Leading article Pseudomembranous colitis. Lancet I (1978) 1080–1081.

    Google Scholar 

  11. Skjelkvålé, R., Duncan, C. L. Enterotoxin formation by different toxigenic types ofClostridium perfringens. Infect. Immun. 11 (1975) 563–575.

    Google Scholar 

  12. Gothefors, L., Blenkharn, I. Clostridium butyricum and necrotising enterocolitis. Lancet I (1978) 52–53.

    Google Scholar 

  13. Larson, H. E., Price, A. B., Honour, P., Borriello, S. P. Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet I (1978) 1063–1066.

    Google Scholar 

  14. Hill, M. J., Drasar, B. S., Aries, V., Crowther, V. S., Hawksworth, G., Williams, R. E. O. Bacteria and aetiology of cancer of large bowel. Lancet I (1971) 95–100.

    Google Scholar 

  15. Lowenfels, A. B. Does bile promote extra-colonic cancer? Lancet II (1978) 239–241.

    Google Scholar 

  16. Hill, M. J., Morson, B. C., Bussey, H. J. R. Aetiology of adenoma-carcinoma sequence in large bowel. Lancet I (1978) 245–247.

    Google Scholar 

  17. Hofmann, A. F. Bile acids, diarrhoea and antibiotics: data, speculation and a unifying hypothesis. J. Infect. Dis. 135 Suppl. (1977) 126–132.

    Google Scholar 

  18. Willis, A. T. Anaerobic bacteriology: Clinical and laboratory practice. Butterworths, London/Boston 1977, pp. 226, 224, 214.

    Google Scholar 

  19. Leading article Brain abscess. Br. Med. J. III (1975) 504–505.

    Google Scholar 

  20. Leading article Treatment of cerebral abscess. Br. med. J. IV (1977) 978.

    Google Scholar 

  21. De Louvois, J., Gortvai, P., Hurley, R. Bacteriology of abscesses of the central nervous system: A multicentre prospective study. Br. Med. J. IV (1977) 981–984.

    Google Scholar 

  22. Ingham, H. R., Selkon, J. B., Roxby, C. M. Bacteriological study of otogenic cerebral abscesses: Chemotherapeutic role of metronidazole. Br. Med. J. IV (1977) 991–993.

    Google Scholar 

  23. Ingham, H. R., High, A. S., Kalbag, R. M., Sengupta, R. P., Tharagonnet, D., Selkon, J. B. Abscesses of the frontal lobe of the brain secondary to covert dental sepsis. Lancet II (1978) 497–499.

    Google Scholar 

  24. Watt, B., Jack, E. P. What are anaerobic cocci? J. Med. Microbiol. 10 (1977) 461–468.

    Google Scholar 

  25. Sisson, P. R., Ingham, H. R., Selkon, J. B. A study of carbon-dioxide-dependent strains ofStreptococcus milleri. J. Med. Microbiol. 11 (1978) 111–116.

    Google Scholar 

  26. Bartlett, J. G., Finegold, S. M. Anaerobic pleuropulmonary infections. Medicine 51 (1972) 413–450.

    Google Scholar 

  27. Collee, J. G. Are anaerobic pleuropulmonary infections uncommon or commonly undetected in Britain? Scand. J. Infect. Dis. Suppl. 19 (1979) 68–73.

    Google Scholar 

  28. Ingham, H. R., Sisson, P. R., Tharagonnet, D., Selkon, J. B., Codde, A. A. The inhibition of phagocytosis in vitro by obligate anaerobes. Lancet II (1977) 1252–1254.

    Google Scholar 

  29. Study group Metronidazole in the prevention and treatment ofBacteroides infections following appendicectomy. Br. Med. J. I (1976) 318–321.

    Google Scholar 

  30. Study group An evaluation of metronidazole in the prophylaxis and treatment of anaerobic infections in surgical patients. J. Antimicrob. Chemother. 1 (1975) 393–401.

    Google Scholar 

  31. Study group Metronidazole in the prevention and treatment ofBacteroides infections in gynaecological patients. Lancet II (1974) 1540–1543.

    Google Scholar 

  32. Kelly, M. J. The quantitative and histological demonstration of pathogenic synergy betweenEscherichia coli andBacteroides fragilis in guinea-pig wounds. J. Med. Microbiol. 11 (1978) 513–523.

    Google Scholar 

  33. Mancini, C., Behme, R. J. Transfer of multiple antibiotic resistance fromBacteroides fragilis toEscherichia coli. J. Infect. Dis. 136 (1977) 597–600.

    Google Scholar 

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Authors and Affiliations

  1. Department of Bacteriology, University Medical School, EH8 9AG, Edinburgh, United Kingdom

    J. G. Collee

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  1. J. G. Collee
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Collee, J.G. Mechanisms of pathogenicity of anaerobic bacteria of clinical interest. Infection 8 (Suppl 2), S113–S117 (1980). https://doi.org/10.1007/BF01639866

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