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Serumkomplementabfall vor Hepatitis-B-Manifestation bei chronisch dialysierten Patienten

Fall in serum complement prior to manifestation of hepatitis B in patients on chronic haemodialysis

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Zusammenfassung

Aufgrund einer Komplementlangzeitstudie bei chronisch dialysierten Patienten konnte CH 50 im Serum vor Manifestwerden einer Hepatitis-B-Infektion an Hand von vier Dialysepatienten verfolgt werden. Dabei trat bei allen vier Patienten ein mäßig stark ausgeprägter Komplementabfall ein bis drei Monate vor dem erstmaligen serologischen Nachweis von Hepatitis-B-Surface-Antigen auf. Die Komplementdepression lag jeweils zeitlich auch vor dem Transaminaseanstieg. Der maximale Abfall der Komplementaktivität betrug im Durchschnitt 27%.

Summary

Haemolytic complement activity was measured in a long-term study in patients on haemodialysis. Four of the patients studied developed hepatitis B while under investigation. In all four patients a fall in haemolytic complement activity was observed one to three months before hepatitis B surface antigen was detected in the serum. The fall in complement activity also occurred prior to a rise in transaminase. The maximum fall averaged 27%.

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Literatur

  1. Almeida, J. D., Waterson, A. P.: Immune complexes in hepatitis. Lancet (1969/II) 983–986.

  2. Bläker, F., Fischer, K., Witte, P. Quantitative Komplement-analysen (C' 3) mit der radialen Immundiffusion bei Erkrankungen mit gestörter Immunitätslage. Dtsch. med. Wschr. 39 (1969) 1978–1982.

    Google Scholar 

  3. Grob, P. J., Jemelka, H. J., Müller, J. W. B1A and SH antigen in chronic hepatitis. Gastroenterology 61 (1971) 91–95.

    Google Scholar 

  4. Jordan, F. J. The significantion of the complement test in liver diseases with jaundice. Acta med. scand. 144 (1953) 268–274.

    Google Scholar 

  5. Kaneyama, L. Studies on the complement titer in liver disease. J. Okayama med. Ass. 71 (1959) 7009–7014.

    Google Scholar 

  6. Lander, J. J., Giles, J. P., Purcell, R. H., Krugman, S. Viral hepatitis Type B (MS-2 strain). Detection of antibody after primary infections. New Engl. J. Med. 285 (1971) 303–307.

    Google Scholar 

  7. Maynard, J. E., Berquist, K. R., Krushak, D. H. Experimental infection of chimpanzees with the virus of Hepatitis-B. Nature 237 (1972) 514–515.

    Google Scholar 

  8. Kabat, E. A., Mayer, M. M. Experimental immunochemistry. Charles C. Thomas, Springfield, Ill., 1961.

    Google Scholar 

  9. Millman, I., London, W. T., Sutnick, A. L. Australia antigen-antibody complexes. Nature 226 (1970) 83–84.

    Google Scholar 

  10. Perri, T. di, Auteri, A. Immune complexes and hepatic disorders. New Engl. J. Med. 285 (1971) 1203–1209.

    Google Scholar 

  11. Ruddy, S., Gigli, I., Austen, F. The complement system of man. New Engl. J. Med. 287 (1972) 545.

    Google Scholar 

  12. Schmidt, P. Boros, Eibl, M., Deutsch, E. Verhlaten der Serumkomplements (CH 50) bei chronisch dialysierten Patienten. Wien. klin. Wschr. 86 (1974) 687–691.

    Google Scholar 

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Authors and Affiliations

  1. Institut für Immunologie der Universität Wien, Borschkegasse 8 a, A-1090, Wien

    M. Eibl

  2. I. Medizinische Universitätsklinik, Lazarettgasse 14, A-1090, Wien

    P. Schmidt &  E. Deutsch

Authors
  1. M. Eibl
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  2. P. Schmidt
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  3. E. Deutsch
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Eibl, M., Schmidt, P. & Deutsch, E. Serumkomplementabfall vor Hepatitis-B-Manifestation bei chronisch dialysierten Patienten. Infection 5, 197–199 (1977). https://doi.org/10.1007/BF01639758

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  • DOI: https://doi.org/10.1007/BF01639758

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