Summary
In order to obtain Haemophilus influenzae, other than Type b, with highly probable human pathogeniticy strains were collected that had been isolated in abundant numbers from middle ear or maxillary sinus secretions of 157 patients with otitis media or sinusitis. The distribution of serotypes was as follows: nontypable 33.8%, Type b 26.1%, Type a 19.1%, Type c 7.6%, Type e 5.7%, Type f 5.1%, and Type d 2.5%. The type distribution did not depend on the source of the strains. All strains were susceptible to ampicillin and amoxycillin in vitro; the broth dilution minimum inhibitory concentrations (MIC) of both antibiotics varied only fourfold; typical MIC values were 0.125µg/ml and 0.25µg/ml, respectively. Susceptibility did not vary with the source or type of the strains nor with the presence or absence of concomitant penicillin therapy.
Zusammenfassung
Um Haemophilus influenzae mit einer vermutlich Menschenpathogenität zu erhalten, die nicht dem Typ b zugeordnet wurden, wurden Stämme gesammelt, die in großer Zahl aus dem Mittelohr oder dem Sinus maxillaris bei 157 Patienten mit Otitis media oder Sinusitis gewonnen wurden. Die Verteilung auf die verschiedenen Typen war folgende: nicht typisierbar 33,8%, Typ b 26,1%, Typ a 19,1%, Typ c 7,6%, Typ e 5,7%, Typ f 5,1% und Typ d 2,5%. Bei dieser Untersuchung hing die Typenverteilung nicht von dem Fundort der Stämme ab. Alle Stämme waren Amoxycillin- und Ampicillin-empfindlich. Die minimale Hemmkonzentration im Reihenverdünnungstest schwankte bei allen Antibiotika im Maximum um das Vierfache, bei den typischen Stämmen betrug sie 0,125 bzw. 0,25µg/ml. Die Antibiotika-Empfindlichkeit schwankte weder zwischen den verschiedenen Isolierungsorten, noch zwischen den verschiedenen Typen, noch in Abhängigkeit von der gleichzeitig durchgeführten Penicillin-Therapie.
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Jokipii, A., Jokipii, L. Haemophilus influenzae in otitis media and sinusitis: Serotypes and susceptibility to ampicillin and amoxycillin in vitro. Infection 5, 140–143 (1977). https://doi.org/10.1007/BF01639748
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DOI: https://doi.org/10.1007/BF01639748