Summary
Staphylococcal scalded skin syndrome, a disease rarely reported in adults, developed in a 38-year-old male while on steroid therapy for chronic active hepatitis. Studies of immunologic parameters important in staphylococcal host defense revealed normal opsonic activity and phagocytic function but marked defects in neutrophil chemotaxis and T-lymphocyte function. Compromised host defense appears to play a significant role in the pathogenesis of the syndrome in adults.
Zusammenfassung
Die Dermatitis exfoliativa, die bei Erwachsenen selten beschrieben wurde, bildete sich bei einem 38 Jahre alten Patienten aus, der wegen einem aktiven Hepatitis unter Steroidtherapie stand. Dabei wiesen die Parameter, die für die Staphylokken-immunabwehr wichtig sind, nämlich die Opsoninaktivität und Phagocytose, eine normale Funktion auf. Es bestanden aber eindeutige Defekte der neutrophilen Chemotaxis und der T-Lymphocyten-Funktion. Gestörte Abwehrfähigkeit der erwachsenen Patienten scheint eine signifikante Bedeutung in der Pathogenese der Syndroms einzunehmen.
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Peterson, P.K., Laverdiere, M., Sabath, L.D. et al. Abnormal neutrophil chemotaxis and T-lymphocyte function in staphylococcal scalded skin syndrome in an adult patient. Infection 5, 128–131 (1977). https://doi.org/10.1007/BF01639745
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DOI: https://doi.org/10.1007/BF01639745