Skip to main content
SpringerLink
Log in

The role of Actinobacillus actinomycetemcomitans in periodontal disease

Bedeutung von Actinomyces actinomycetemcomitans bei Periodontitis

  • Addendum I
  • The Impact of Microbial Ecology on Clinical Problems International Symposium Weitenburg/Tübingen, June 1988
  • Published:
Infection Aims and scope Submit manuscript

Summary

The different forms of periodontitis are all associated with a distinct bacterial flora. However, a clear relationship is described between localized juvenile periodontitis (LJP) andActinobacillus actinomycetemcomitans. Eleven LJP patients all harbouredA. actinomycetemcomitans. The arrest of LJP is often impossible, due to the inability to eliminateA. actinomycetemcomitans. Therefore, antibiotic treatment was introduced in combination with the initial treatment. We studied the effect of periodontal treatment on the microflora and clinical status of periodontal disease patients using different therapies. Group 3 attained the best results (initial treatment and a combination metronidazole and amoxicillin), the group to eliminateA. actinomycetemcomitans effectively.

Zusammenfassung

Die verschiedenen Formen der Periodontitis unterscheiden sich durch eine charakteristische bakterielle Flora. Eine eindeutige Beziehung konnte jedoch zwischen der Localized Juvenile Periodontitis (LJP) und demActinobacillus actinomycetemcomitans nachgewiesen werden. Bei elf untersuchten LJP-Patienten konnteA. actinomycetemcomitans isoliert werden. Der LJP Einhalt zu gebieten ist oft deshalb unmöglich, weil es nicht gelingt,A. actinomycetemcomitans zu eliminieren. Deshalb wurde eine antibiotische Therapie zusammen mit der „Initialtherapie“ versucht. Wir haben die Wirkung verschiedener periodontaler Therapien anhand der Mikroflora und des klinischen Befundes untersucht. Die besten Ergebnisse erzielte die Gruppe 3 (Initialtherapie sowie eine Kombination von Metronidazol und Amoxicillin), die einzige Gruppe, dieA. actinomycetemcomitans effektiv abtöten konnte.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Listgartern, M. A. Structure of the microbial flora associated with periodontal health and disease in man. A light and electron microscopic study. J. Periodontol. 47 (1986) 1–18.

    Google Scholar 

  2. Lindhe, J. Treatment of localized juvenile periodontitis. In:Genco, R. J., Mergenhagen, S. E. (eds): Host-parasite interactions in periodontal diseases. Washington D.C., ASM (1982) pp. 382–394.

    Google Scholar 

  3. Klinger, R. Untersuchungen über menschliche Aktinomykose. Zentralblatt für Bakteriologie 62 (1912) 191–200.

    Google Scholar 

  4. Colebrook, L. The mycelial and other microorganisms associated with human actinomycosis. Br. J. Exp. Pathol. 1 (1920) 197–212.

    Google Scholar 

  5. Holm, P. Studies of the aetiology of human actinomycosis. I. The “other microbes” of actinomycosis and their importance. Acta Pathol. Microbiol. Scand. 27 (1951) 736–750.

    Google Scholar 

  6. Bayne-Jones, S. Club-formation byActinomyces hominis in glucose broth with a note onB. actinomycetemcomitans. J. Bacteriol. 10 (1925) 569–577.

    Google Scholar 

  7. Holm, P. Studies on the aetiology of human actinomycosis. II. Do the “other microbes” of actinomycosis possess virulence. Acta Pathol. Microbiol. Scand. 28 (1951) 391–406.

    Google Scholar 

  8. Heinrich, S., Pulverer, G. Zur Aetiologie und Microbiologie der Aktinomycose. III. Die pathogene Bedeutung desActinobacillus actinomycetem-comitans und den „Begleitbakterien“ desActinomyces israelii. Zbl. Bakteriol. Parasitenk. Infektionskr. Hyg. Abt. Orig. 176 (1959) 91–101.

    Google Scholar 

  9. Kilian, M., Schiott, C. R. Haemophili and related bacteria in the human oral cavity. Arch. Oral Biol. 20 (1975) 791–796.

    Google Scholar 

  10. Slots, J., Reynolds, H. S., Genco, R. J. Actinobacillus actinomycetemcomitans in human periodontal disease: a cross-sectional microbiological investigation. Infect. Immun. 29 (1980) 1013–1020.

    Google Scholar 

  11. Mandell, R. L., Socransky, S. S. A selective medium forActinobacillus actinomycetem-comitans and the incidence of the organism in juvenile periodontitis. J. Periodontol. 52 (1981) 593–598.

    Google Scholar 

  12. Slots, J. Selective medium for isolation ofActinobacillus actinomycetemcomitans. J. Clin. Microbiol. 15 (1982) 606–609.

    Google Scholar 

  13. Zambon, J. L., Christersson, L. A., Slots, J. Actinobacillus actinomycetemcomitans in human periodontal disease: prevalence in patient groups and distribution of biotypes and serotypes within families. J. Periodontol. 54 (1983) 707–711.

    Google Scholar 

  14. Eisenmann, A. C., Eisenmann, R., Sousa, O., Slots, J. Microbiological study of localized periodontitis in Panama. J. Periodontol. 54 (1983) 712–713.

    Google Scholar 

  15. Bragd, L., Dahlen, G., Wikstrom, M., Slots, J. The capacity ofActinobacillus actinomycetemcomitans, Bacteroides gingivalis andBacteroides intermedius to indicate progressive periodontitis; a retrospective study. J. Clin. Microbiol. 14 (1987) 95–99.

    Google Scholar 

  16. Bragd, J., Wikstrom, M., Dahlen, G., Slots, J. The occurrence ofActinobacillus actinomycetemcomitans, Bacteroides gingivalis andBacteroides intermedius in destructive periodontal disease in adults. J. Clin. Periodontol. 13 (1986) 570–577.

    Google Scholar 

  17. van Winkelhoff, A. J., Rodenburg, J. P., Goene, R. J., Abbas, F., Winkel, E. G., de Graaff, J.: Metronidazole plus amoxicillin in the treatment ofActinobacillus actinomycetemcomitans associated periodontitis. J. Clin. Periodontol. (in press) (1989).

  18. Genco, R. J., Slots, J., Mouton, C., Murray, P. Systemic immune response to oral anaerobic organisms. In:Lambe, D. W., Genco, R. J., Mayberry-Carson, K. J. (eds.): Anaerobic bacteria: selected topics. Plenum Publishing Corp., New York 1980.

    Google Scholar 

  19. Ebersole, J. L., Taubman, M. A., Smith, D. J., Genco, R. J., Frey, D. E. Human immune response to oral microorganisms. I. Association of localized juvenile periodontitis (LJP) with serum antibody response toActinobacillus actinomycetemcomitans. Clin. Exp. Immunol. 47 (1982) 43–52.

    Google Scholar 

  20. Ranney, R. R., Yanni, N. R., Burmeister, J. A., Tew, J. G. Relationship between attachment loss and precipitating serum antibody toActinobacillus actinomycetemcomitans in adolescents and young adults having severe periodontal destruction. J. Periodontol. 53 (1982) 1–7.

    Google Scholar 

  21. Baehni, P. C., Tsai, C.-C., McArthur, W. P., Hammond, B. F., Taichman, T. S. Leukotoxic activity in different strains of the bacteriumActinobacillus actinomycetemcomitans isolated from juvenile periodontitis in man. Arch. Oral Biol. 26 (1981) 671–676.

    Google Scholar 

  22. Tsai, C.-C., Shenker, B. J., DiRienzo, J. M., Malamud, D., Taichman, N. S. Extraction and isolation of a leukotoxin fromActinobacillus actinomycetemcomitans with polymixin B. Infect. Immun. 43 (1984) 700–705.

    Google Scholar 

  23. Slots, J., Rosling, B. Suppression of the periodontopathic microflora in localized juvenile periodontitis by systemic tetracycline. J. Clin. Periodontol. 10 (1983) 465–486.

    Google Scholar 

  24. Christersson, L. A., Bothello, M., Wikeslo, U. M. E., Bonta, Y., Zambon, J. J. Suppression ofA. actinomycetemcomitans using systemic tetracycline, in patients with localized juvenile periodontitis. J. Dent. Res. 64 (1985) 305 abstract 1170.

    Google Scholar 

  25. Genco, R. J., Cianciola, B., Rosling, B. Treatment of localized juvenile periodontitis. J. Dent. Res. 60 (1981) 527 abstract 872.

    Google Scholar 

  26. Gillett, R., Johnson, N. W. Bacterial invasion of the periodontium in a case of juvenile periodontitis. J. Clin. Periodontol. 9 (1982) 93–100.

    Google Scholar 

  27. Christersson, L. A., Albini, B., Zambon, J. J., Slots, J., Genco, R. J. Demonstration ofActinobacillus actinomycetemcomitans in gingiva of localized juvenile periodontitis lesions. J. Dent. Res. 62 (1983) 198 abstract 255.

    Google Scholar 

  28. Kornman, K. S., Robertsen, P. D. Clinical and microbiological evaluation of therapy for juvenile periodontitis. J. Periodontol. 56 (1985) 443–446.

    Google Scholar 

  29. Lindhe, J. Treatment of localized juvenile periodontitis. In:Genco, R. J., Mergenhage, S. E. (eds.): Host-parasite interactions in periodontal disease. Washington D.C., ASM (1982) 27–45.

    Google Scholar 

  30. Mandell, R. L., Tripodi, L. S., Savitt, E., Goodson, J. M., Socransky, S. S. The effect of treatment onActinobacillus actinomycetemcomitans in localized juvenile periodontitis. J. Periodontol. 57 (1986) 95–99.

    Google Scholar 

  31. Mandell, R. L., Socransky, S. S. Microbiological and clinical effects of surgery plus doxycycline on juvenile periodontitis. J. Periodontol. 59 (1988) 373–379.

    Google Scholar 

  32. Christersson, L. A., Slots, J., Rosling, B. G., Genco, R. J. Microbiological and clinical effects of surgical treatment of localized juvenile periodontitis. J. Clin. Periodontol. 12 (1985) 465–476.

    Google Scholar 

  33. Zambon, J. J. Actinobacillus actinomycetemcomitans in human periodontal disease. J. Clin. Periodontol. 12 (1985) 1–20.

    Google Scholar 

  34. Grace, C. J., Levitz, R. E., Katz-Pollak, H., Brettman, L. R. Actinobacillus actinomycetemcomitans prosthetic valve endocarditis. Rev. Infect. Diseases 10 (1988) 922–929.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oral Microbiology, Academic Centre for Dentistry (ACTA), van der Boechorststraat 7, NL-1081 BT, Amsterdam

    J. de Graaff &  A. J. Winkelhoff

  2. The Clinic for Periodontology Amsterdam, de Boelelaan 589, NL-1082 RM, Amsterdam

    R. J. Goene

Authors
  1. J. de Graaff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. J. Winkelhoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. J. Goene
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

de Graaff, J., Winkelhoff, A.J. & Goene, R.J. The role of Actinobacillus actinomycetemcomitans in periodontal disease. Infection 17, 269–271 (1989). https://doi.org/10.1007/BF01639538

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01639538

Keywords

Search

Navigation