Summary
Fifty-five ambulatory children with early culture-proven pertussis were treated for two weeks either with erythromycin ethylsuccinate (n=28) (50–80 mg/kg/day in three doses during meals) or with co-trimoxazole (n=27) (6–10 mg trimethoprim/kg/day in two doses after meals). After completion of treatment, all patients in the erythromycin group were culture-negative, while in the co-trimoxazole group one child was still culture-positive. In this case vomiting may have played a role. Both agents appear to be able to eradicateBordetella pertussis from the nasopharynx of patients with early whooping cough.
Zusammenfassung
Fünfundfünfzig ambulante Kinder mit kulturell bestätigtem Keuchhusten im Frühstadium wurden zwei Wochen lang entweder mit Erythromycin-Äthylsuccinat (n=28) (50–80 mg/kg/Tag in drei Einzeldosen während der Mahlzeiten) oder mit Co-trimoxazol (n=27) (6–10 mg Trimethoprim/kg/Tag in zwei Einzeldosen nach den Mahlzeiten) behandelt. Nach Therapieende waren alle Patienten in der Erythromycin-Gruppe kulturnegativ, während bei einem Kind in der Co-trimoxazol-Gruppe die Kultur noch positiv war. In diesem Fall hat möglicherweise Erbrechen eine Rolle gespielt. Beide Testmedikamente scheinen in der Lage zu sein,Bordetella pertussis aus dem Nasopharynx von Patienten mit frühem Keuchhusten zu eliminieren.
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Hoppe, J.E., Halm, U., Hagedorn, H.J. et al. Comparison of erythromycin ethylsuccinate and co-trimoxazole for treatment of pertussis. Infection 17, 227–231 (1989). https://doi.org/10.1007/BF01639525
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DOI: https://doi.org/10.1007/BF01639525