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Klinische Erfahrungen mit Cefotaxim bei antiinfektiöser Therapie zytostatisch behandelter Kinder

Clinical experience with cefotaxime in antiinfection therapy of children treated with cytotoxic drugs

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Zusammenfassung

Die Wirksamkeit und Verträglichkeit von Cefotaxim wurde an fünf Kindern mit schwer verlaufenden Infektionen überprüft, die unter hochdosierter zytostatischer Therapie bei Leukämien bzw. maligner Histiozytose standen. Im Hinblick auf die myelo- und immunosuppressive Wirkung der Zytostatika wurden alle Kinder bereits vor der Therapie mit Cefotaxim prophylaktisch mit Antibiotika oder Chemotherapeutika behandelt. Ein eindeutiger Therapieerfolg wurde bei vier Kindern erzielt. Wesentliche Nebenwirkungen der Cefotaxim-Therapie wurden nicht beobachtet.

Summary

The effectiveness and tolerance of cefotaxime was examined in five children with severe infections who were being treated with high doses of cytotoxic drugs for leukemia or malignant histiocytosis. On account of the myelosuppressive and immunosuppressive effects of the cytotoxic drugs, all children had been treated prophylactically with antibiotics or chemotherapeutic agents prior to therapy with cefotaxime. In four children therapy was clearly successful. No serious side-effects of cefotaxime therapy were observed.

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Literatur

  1. Levine, A. S., Schimpff, S. C., Graw, R. G., Young, R. C. Hematologic malignancies and other marrow failure states: Progress in the management of complicating infections. Semin. Hematol. 11 (1974) 141–202.

    Google Scholar 

  2. Hughes, W. T., Feldmann, S., Sanyal, S. K. Treatment of pneumocystis carinii pneumonitis with trimethoprim-sulphamethoxazole. Can. Med. Ass. J. 112 Special No. (1975) 47–52.

    Google Scholar 

  3. Gadner, H., v. Lengerke, H., Steinbart, J., Riehm, H. Acute lymphoblastic leukemia (all) in children: Prophylaxis of interstitial pneumonia with pentamidine isothionate (PI) during aggressive multiple drug induction chemotherapy. International Congress of Hematology, Jerusalem 1974, Abstract II, 449.

    Google Scholar 

  4. Riehm, H., Gadner, H., Welte, K. Die West-Berliner Studie zur Behandlung der akuten lymphoblastischen Leukämie des Kindes — Erfahrungsbericht nach 6 Jahren. Klin. Pädiatr. 189 (1977) 89–102.

    Google Scholar 

  5. Linzenmeier, G., Rosenthal, E. Zur In-vitro-Testung der neueren Cephalosporine. Infection 7 (1979) 225–227.

    Google Scholar 

  6. Hamilton-Miller, J. M. T., Brumfitt, W., Reynolds, A. V. Cefotaxime (HR 756) a new cephalosporin with exceptional broad-spectrum activity in vitro. J. Antimicrob. Chemother. 4 (1978) 437–444.

    Google Scholar 

  7. Chabbert, Y. A., Lutz, A. J. HR 756, the syn isomer of a new methoxyimino cephalosporin with unusual antibacterial activity. Antimicrob. Agent. Chemother 14 (1978) 749–754.

    Google Scholar 

  8. Naumann, P., Rosin, H. Fortschritte in der antibakteriellen Chemotherapie. Internist. 19 (1978) 664–671.

    Google Scholar 

  9. Wise, R., Rollason, T., Logan, M., Andrews, J. M., Bedford, K. A. HR 756, a highly active cephalosporin: Comparison with cefazolin and carbenicillin. Antimicrob. Agent. Chemother. 14 (1978) 807–811.

    Google Scholar 

  10. Frottier, J. Les céphalosporines. Méd. Hyg. 36 (1978) 434–440.

    Google Scholar 

  11. v. Landuyt, H. W., Pyckavet, M.: In vitro activity of RU. 24756 against cephalothin resistant clinical isolates. 18. Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta 1978, Abstract 296.

  12. Acar, J. F., Husson, J. M., Guibert, J., Humbert, G., Kitzis, M. D., Esmieu, F.: HR 756 Pharmacokinetics. Preliminary therapeutic results in severe human infections. 18. Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta 1978, Abstract 82.

  13. Shah, P. M., Helm, E. B., Stille, W. Klinische Erfahrungen mit Cefotaxim, einem neuen Cephalosporinderivat. Med. Welt 30 (1979) 298–301.

    Google Scholar 

  14. Graninger, W., Breyer, S., Pichler, H. Mikrobiologische und klinische Erfahrungen mit Cefoxitin. Infection 7 Suppl. 1 (1979) 99–102.

    Google Scholar 

  15. Marget, W., Belohradsky, B., Roos, R.: Effect of revised drug schedules with the cephalosporine HR 756 on the treatment of severe infections. 18. Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta 1978, Abstract 296.

  16. Scheer, U., Schellong, G., Riehm, H. Verbesserte Prognose der akuten myeloischen Leukämie bei Kindern nach intensivierter Anfangstherapie. Klin. Pädiatr. 191 (1979) 104–110.

    Google Scholar 

  17. Rosen, G., Caparros, B., Mosende, C., McCormick, B., Huvos, A. G., Marcove, R. C. Curability of Ewing's sarcoma and considerations for future therapeutic trials. Cancer 41 (1978) 888–899.

    Google Scholar 

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Authors and Affiliations

  1. Universitäts-Kinderklinik und Poliklinik der Universität Göttingen, Humboldtallee 38, D-3400, Göttingen

    H. H. Peters,  W. Tillmann &  W. Schröter

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  1. H. H. Peters
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  2. W. Tillmann
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  3. W. Schröter
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Peters, H.H., Tillmann, W. & Schröter, W. Klinische Erfahrungen mit Cefotaxim bei antiinfektiöser Therapie zytostatisch behandelter Kinder. Infection 8 (Suppl 4), S513–S515 (1980). https://doi.org/10.1007/BF01639435

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