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Cefotaxim-Empfindlichkeit von Pseudomonas aeruginosa im Vergleich zu Aminoglykosiden, Alpha-Carboxypenicillin und Ureidopenicillinen

Sensitivity of pseudomonas aeruginosa to cefotaxime in comparison to aminoglycosides, alpha-carboxy-penicillin and ureidopenicillin

  • Mikrobiologie
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Zusammenfassung

Es wurde die In-vitro-Aktivität von Cefotaxim gegen 123Pseudomonas aeruginosa-Stämme im Agar-Diffusionstest bestimmt und mit den beiden Aminoglykosiden Gentamycin und Tobramycin, dem Alpha-Carboxypenicillin Ticarcillin und den beiden Ureidopenicillinen Azlocillin und Mezlocillin verglichen. Dabei zeigte sich, daß in vitro Cefotaxim gegen 87% der untersuchten Stämme wirksam war und damit in der Rangliste der Pseudomonas-wirksamen Antibiotika zwischen Mezlocillin mit 84% und Ticarcillin mit 89% steht. Die bisher nur spärlichen klinischen Untersuchungen müssen intensiviert werden.

Summary

By means of the agar diffusion test the in vitro activity of cefotaxime against 123 strains ofPseudomonas aeruginosa was determined and compared with the two aminoglycosides gentamycin and tobramycin, the alpha-carboxypenicillin ticarcillin, and the two ureidopenicillins azlocillin and mezlocillin. It could be shown that cefotaxime was effective in vitro against 87% of the strains tested and can thus be placed between mezlocillin (84%) and ticarcillin (89%) on the list of antibiotics acting againstPseudomonas. Clinical investigation, which has hitherto been limited, must be intensified.

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Literatur

  1. Knudson, E. T., Rolinson, G. N., Sutherland, R. Carbenicillin: A new semisynthetic penicillin active againstPseudomonas pyocyanea. Br. Med. J. III (1967) 75–78.

    Google Scholar 

  2. Heymes, R., Lutz, A., Schrinner, E. Experimental evaluation of HR 756, a new cephalosporin derivate: Pre-clinical study. Infection 5 (1977) 259–260.

    Google Scholar 

  3. Deutsches Institut für Normung Methoden zur Empfindlichkeitsprüfung von bakteriellen Krankheitserregern gegen Chemotherapeutika. DIN 58 940, Teil 1-6. Beuth Verlag, Berlin 1978.

    Google Scholar 

  4. Basker, M. J., Edmundson, A. E., Sutherland, R. Comparative antibacterial activity of azlocillin, mezlocillin, carbenicillin and ticarcillin and relative stability to β-lactamase ofPseudomonas aeruginosa andKlebsiella aerogenes. Infection 7 (1979) 67–73.

    Google Scholar 

  5. Sosna, J. P., Murray, P. R., Medoff, G. Comparison of the in vitro activities of HR 756 with cephalothin, cefoxitin and cefamandole. Antimicrob. Agents Chemother. 14, (1978) 876–879.

    Google Scholar 

  6. Neu, H. C., Aswapokee, N., Aswapokee, P., Fu, K. P. HR 756, a new cephalosporin active against gram-positive and gram-negative aerobic and anaerobic bacteria. Antimicrob. Agents Chemother. 15 (1979) 273–281.

    Google Scholar 

  7. Shah, P. M., Troche, G., Stille, W. In vitro activity of HR 756, a new cephalosporin compound. J. Antibiot. 31 (1978) 1170–1174.

    Google Scholar 

  8. Wise, R., Rollason, T., Logan, M., Andrews, J. M., Bedford, K. A. HR 756, a high active cephalosporin: Comparison with cefazolin and carbenicillin. Antimicrob. Agents Chemother. 14 (1978) 807–811.

    Google Scholar 

  9. Johnson, P., Glomot, R., Kramer, M.: HR 756 — Kinetics, metabolism and toxicology. Abstracts, 18th Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta 1978.

  10. Ninane, G. Cefotaxim (HR 756) and nephrotoxicity. Lancet I (1979) 332.

    Google Scholar 

  11. Bauernfeind, A., Petermüller, Ch., Dietzel, M. Zur aktuellen Chemotherapie von Infektionen mitPseudomonas aeruginosa. Infection 7 (1979) 21–26.

    Google Scholar 

  12. Drasar, F. A., Farell, W., Howard, A. J., Hince, C., Leung, T., Williams, J. D. Activity of HR 756 againstHaemophilus influenzae, Bacteroides fragilis and gram-negative rods. J. Antimicrob. Chemother. 4 (1978) 445–450.

    Google Scholar 

  13. Drugon, H., Courtieu, A. L.: A new semi-synthetic cephalosporin. Abstracts, 1st Mediterranean Congress Chemotherapy, Madrid 1978.

  14. Marget, W., Belohradsky, B., Roos, R.: Effect of revised drug schedules with the cephalosporin HR 756 on the treatment of severe infections. Abstracts, 18th Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta 1978.

  15. Naumann, P., Rosin, H. Fortschritte in der antibakteriellen Chemotherapie. Internist 19 (1978) 664–671.

    Google Scholar 

  16. Primavesi, C. A. Bakteriologische Untersuchungen mit Cefotaxim, einem neuen Cephalosporin. Med. Welt 30 (1979) 1407–1409.

    Google Scholar 

  17. Stephens, M., Potten, M., Bint, A. J. The sensitivity of gentamycin-resistent, gram-negative bacilli to cefotaxim, other cephalosporins and aminoglycosides. Infection 7 (1979) 109–112.

    Google Scholar 

  18. Wagner, W.-H. Die gegenwärtige Resistenzsituation. Immun. Infek. 6 (1978) 180–193.

    Google Scholar 

  19. Graninger, W., Breyer, S., Pichler, H. Mikrobiologische und klinische Erfahrungen mit Cefoxitin. Infection 7 Suppl. 1 (1979) 99–102.

    Google Scholar 

  20. Hamilton-Miller, J. M. T., Brumfitt, W., Reynolds, A. V. Cefotaxime (HR 756) a new cephalosporin with exceptional broad-spectrum activity in vitro. J. Antimicrob. Chemother. 4 (1978) 437–444.

    Google Scholar 

  21. Larson, N. J., Holloway, W. J.: In vitro activity of HR 756. Abstracts, 18th Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta 1978.

  22. Linzenmeier, G., Rosenthal, E. Zur In-vitro-Testung der neueren Cephalosporine. Infection 7 Suppl. 2 (1979) 225–227.

    Google Scholar 

  23. Neu, H. C., Aswapokee, N., Fu, K. P.: HR 756: A novel β-lactamase resistant cephalosporin. Abstracts, 18th Interscience Conference Antimicrobial Agents and Chemotherapy, Atlanta 1978.

  24. Shah, P. M., Helm, F. B., Stille, W. Klinische Erfahrungen mit Cefotaxim, einem neuen Cephalosporin-Derivat, Med. Welt 30 (1979) 298–301.

    Google Scholar 

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  1. Landesmedizinaluntersuchungsamt, Rubensstr. 111, D-1000, Berlin 41

    B. Neuhaus

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  1. B. Neuhaus
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Neuhaus, B. Cefotaxim-Empfindlichkeit von Pseudomonas aeruginosa im Vergleich zu Aminoglykosiden, Alpha-Carboxypenicillin und Ureidopenicillinen. Infection 8 (Suppl 4), S430–S432 (1980). https://doi.org/10.1007/BF01639412

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